PYRAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alphaVbeta5 integrin w...

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Hauptverfasser: ALBERT KHILEVICH, YAPING WANG, MARK, L. BOYS, PREETE GANDHI, MARK RUSSELL, RENEE, M. HUFF, VICTORIA DOWNS, THOMAS, D. PENNING, DALE, P. SPANGLER, BARBARA, B. CHEN
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creator ALBERT KHILEVICH
YAPING WANG
MARK, L. BOYS
PREETE GANDHI
MARK RUSSELL
RENEE, M. HUFF
VICTORIA DOWNS
THOMAS, D. PENNING
DALE, P. SPANGLER
BARBARA, B. CHEN
description The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alphaVbeta5 integrin without significantly inhibiting the alphaVbeta6 integrin.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PYRAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES
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