Acyloxypyrrolidine derivatives and use thereof as ligands of V1Bor both V1Band V1A receptors

Acyloxypyrrolidine derivatives and use thereof as ligands of V1Bor both V1Band V1A receptors

The invention relates to acyloxypyrrolidine derivatives of general formula (I): in which: R1 represents a hydrogen atom, a (C1-C6)alkyl, a (C3-C6)cycloalkyl, a group -CH2CH2COOH or a group -NR2R3; R2 and R3 each represent, independently, a hydrogen atom or a (C1-C6)alkyl. Also disclosed and claimed...

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Hauptverfasser: CLAUDINE SERRADEIL-LE GAL, JEAN WAGNON, ALAIN AULOMBARD, GEORGES GARCIA, ANTOINE PRADINES
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator CLAUDINE SERRADEIL-LE GAL
JEAN WAGNON
ALAIN AULOMBARD
GEORGES GARCIA
ANTOINE PRADINES
description The invention relates to acyloxypyrrolidine derivatives of general formula (I): in which: R1 represents a hydrogen atom, a (C1-C6)alkyl, a (C3-C6)cycloalkyl, a group -CH2CH2COOH or a group -NR2R3; R2 and R3 each represent, independently, a hydrogen atom or a (C1-C6)alkyl. Also disclosed and claimed are the method of preparation of the compounds of the invention and their application in therapeutics.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Acyloxypyrrolidine derivatives and use thereof as ligands of V1Bor both V1Band V1A receptors
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