Phenylpyridazine derivatives as ligands for GABA receptors

Phenylpyridazine derivatives as ligands for GABA receptors

A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the alpha2 and/or alpha3 and or alpha5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central ner...

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Hauptverfasser: PETER BLURTON, RICHARD THOMAS LEWIS, MONIQUE BODIL VAN NIEL, WESLEY PETER BLACKABY, LESLIE JOSEPH STREET, ANDREW JENNINGS, STEVE THOMAS, ANGUS MURRAY MACLEOD, STEPHEN ROBERT FLETCHER, KEVIN WILSON, FRANK BURKAMP
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator PETER BLURTON
RICHARD THOMAS LEWIS
MONIQUE BODIL VAN NIEL
WESLEY PETER BLACKABY
LESLIE JOSEPH STREET
ANDREW JENNINGS
STEVE THOMAS
ANGUS MURRAY MACLEOD
STEPHEN ROBERT FLETCHER
KEVIN WILSON
FRANK BURKAMP
description A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the alpha2 and/or alpha3 and or alpha5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Phenylpyridazine derivatives as ligands for GABA receptors
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