HUMAN ADAM-10 INHIBITORS
The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inh...
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| creator | RICHARD, G. KHOURY AMY LEW WEI XU JOHN, M. NUSS MICHAEL, P. PRISBYLLA S., DAVID BROWN LYNNE CANNE ERICK, W. CO MORRISON, B. MAC DONNA, T. LE MOON HWAN KIM VASU JAMMALAMADAKA SHUMEYE MAMO |
| description | The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom. |
| format | Patent |
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PRISBYLLA ; S., DAVID BROWN ; LYNNE CANNE ; ERICK, W. CO ; MORRISON, B. MAC ; DONNA, T. LE ; MOON HWAN KIM ; VASU JAMMALAMADAKA ; SHUMEYE MAMO</creatorcontrib><description>The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.</description><edition>7</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030630&DB=EPODOC&CC=AU&NR=2002346724A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030630&DB=EPODOC&CC=AU&NR=2002346724A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RICHARD, G. KHOURY</creatorcontrib><creatorcontrib>AMY LEW</creatorcontrib><creatorcontrib>WEI XU</creatorcontrib><creatorcontrib>JOHN, M. NUSS</creatorcontrib><creatorcontrib>MICHAEL, P. PRISBYLLA</creatorcontrib><creatorcontrib>S., DAVID BROWN</creatorcontrib><creatorcontrib>LYNNE CANNE</creatorcontrib><creatorcontrib>ERICK, W. CO</creatorcontrib><creatorcontrib>MORRISON, B. MAC</creatorcontrib><creatorcontrib>DONNA, T. LE</creatorcontrib><creatorcontrib>MOON HWAN KIM</creatorcontrib><creatorcontrib>VASU JAMMALAMADAKA</creatorcontrib><creatorcontrib>SHUMEYE MAMO</creatorcontrib><title>HUMAN ADAM-10 INHIBITORS</title><description>The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJDwCPV19FNwdHH01TU0UPD08_B08gzxDwrmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxjqFGBgZGxiZm5kYmjobGxKkCAEYHICA</recordid><startdate>20030630</startdate><enddate>20030630</enddate><creator>RICHARD, G. 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PRISBYLLA</creatorcontrib><creatorcontrib>S., DAVID BROWN</creatorcontrib><creatorcontrib>LYNNE CANNE</creatorcontrib><creatorcontrib>ERICK, W. CO</creatorcontrib><creatorcontrib>MORRISON, B. MAC</creatorcontrib><creatorcontrib>DONNA, T. LE</creatorcontrib><creatorcontrib>MOON HWAN KIM</creatorcontrib><creatorcontrib>VASU JAMMALAMADAKA</creatorcontrib><creatorcontrib>SHUMEYE MAMO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RICHARD, G. KHOURY</au><au>AMY LEW</au><au>WEI XU</au><au>JOHN, M. NUSS</au><au>MICHAEL, P. PRISBYLLA</au><au>S., DAVID BROWN</au><au>LYNNE CANNE</au><au>ERICK, W. CO</au><au>MORRISON, B. MAC</au><au>DONNA, T. LE</au><au>MOON HWAN KIM</au><au>VASU JAMMALAMADAKA</au><au>SHUMEYE MAMO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HUMAN ADAM-10 INHIBITORS</title><date>2003-06-30</date><risdate>2003</risdate><abstract>The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HUMAN ADAM-10 INHIBITORS |
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