Method of selecting substance characterized by assaying PPARD activating effect and drug

Method of selecting substance characterized by assaying PPARD activating effect and drug

Selection (M1) of substances which accelerate thermogenesis, accelerate the uncoupling of respiration in mitochondria, accelerate protein leak in mitochondrial internal membranes, increase the expression level of UCP1 in cells containing mitochondria, and/or accelerate fatty acid beta-oxidation, com...

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Hauptverfasser: KAZUYOSHI YAMAOKA, KENICHIRO KATAOKA, KENICHIRO TAKAGI, TOSHIHIRO CHIKANISHI, MASANORI YAMAMOTO
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Sprache:eng
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator KAZUYOSHI YAMAOKA
KENICHIRO KATAOKA
KENICHIRO TAKAGI
TOSHIHIRO CHIKANISHI
MASANORI YAMAMOTO
description Selection (M1) of substances which accelerate thermogenesis, accelerate the uncoupling of respiration in mitochondria, accelerate protein leak in mitochondrial internal membranes, increase the expression level of UCP1 in cells containing mitochondria, and/or accelerate fatty acid beta-oxidation, comprising selection for activation of peroxisome proliferator activated receptor delta (PPARD), is new. An independent claim is also included for drug compositions containing substances identified by (M1). ACTIVITY : Antidiabetic; Anorectic. MECHANISM OF ACTION : Activation of PPARD. No biological data given.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title Method of selecting substance characterized by assaying PPARD activating effect and drug
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