Process for the preparation of mesylates of piperazine derivatives

Process for the preparation of mesylates of piperazine derivatives

The invention relates to the mesylates of a group of piperazine derivatives and to a process for the preparation of these mesylates in an economic way in the high yield and of high purity. According to the process of the invention the synthesis of the piperazine ring and the mesylate formation are c...

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Hauptverfasser: MICHIEL C. HESLINGA, STEFANUS J. SCHOUTEN, JAN ZORGDRAGER, MARCEL P.M. VAN AAR
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator MICHIEL C. HESLINGA
STEFANUS J. SCHOUTEN
JAN ZORGDRAGER
MARCEL P.M. VAN AAR
description The invention relates to the mesylates of a group of piperazine derivatives and to a process for the preparation of these mesylates in an economic way in the high yield and of high purity. According to the process of the invention the synthesis of the piperazine ring and the mesylate formation are combined in a single reaction step. The invention relates to the mesylate of compounds of the formula (I) wherein X is a bicyclic heterocyclic phenyl group and Y is methyl, ethyl (optionally substituted with fluorine), cycloalkyl (3-7C) methyl, benzyl or m-phenyl benzyl
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Process for the preparation of mesylates of piperazine derivatives
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