Anti-picornaviral ligands via a combinatorial computational and synthetic approach

Anti-picornaviral ligands via a combinatorial computational and synthetic approach

The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.g., anti-picornaviral capsid-binding compound...

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Hauptverfasser: JAMES M. HOGLE, JAMES LI-WEN CHEH, LYLE D. ISAACS, GEORGE M. WHITESIDES, DIANE M. JOSEPH-MCCARTHY, MARTIN KARPLUS
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator JAMES M. HOGLE
JAMES LI-WEN CHEH
LYLE D. ISAACS
GEORGE M. WHITESIDES
DIANE M. JOSEPH-MCCARTHY
MARTIN KARPLUS
description The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.g., anti-picornaviral capsid-binding compounds.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Anti-picornaviral ligands via a combinatorial computational and synthetic approach
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