Improved process for water soluble azole compounds

Improved process for water soluble azole compounds

An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antifungal compounds are provided having the gener...

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Hauptverfasser: TIMOTHY PAUL CONNOLLY, LAXIMA REDDY KOLLA, RICHARD H. MUELLER, DEJAH T. PETSCH, CHUNG-PIN CHEN, JOHN D. MATISKELLA, YADAGIRI RENDRI
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator TIMOTHY PAUL CONNOLLY
LAXIMA REDDY KOLLA
RICHARD H. MUELLER
DEJAH T. PETSCH
CHUNG-PIN CHEN
JOHN D. MATISKELLA
YADAGIRI RENDRI
description An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antifungal compounds are provided having the general formulawherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and R and R1 are as defined in the specification.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Improved process for water soluble azole compounds
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