MAKROMOLEKULARE HAEMOGLOBINKONJUGATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNGEN
PCT No. PCT/FR87/00262 Sec. 371 Date Feb. 3, 1988 Sec. 102(e) Date Feb. 3, 1988 PCT Filed Jul. 2, 1987 PCT Pub. No. WO88/00055 PCT Pub. Date Jan. 14, 1988.The subject of the invention is a water-soluble macromolecular conjugate of hemoglobin characterized in that it is constituted on the one hand, b...
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| creator | LEONARD, MICHELE NEEL, JEAN MAURICE LEON LABRUDE, PIERRE VIGNERON, CLAUDE SACCO, DANIEL DELLACHERIE, EDITH BONNEAUX, FRANCOIS |
| description | PCT No. PCT/FR87/00262 Sec. 371 Date Feb. 3, 1988 Sec. 102(e) Date Feb. 3, 1988 PCT Filed Jul. 2, 1987 PCT Pub. No. WO88/00055 PCT Pub. Date Jan. 14, 1988.The subject of the invention is a water-soluble macromolecular conjugate of hemoglobin characterized in that it is constituted on the one hand, by hemoglobin, on the other, by a water-soluble polymer P containing polar groups, this macromolecular conjugate contains Z sites, bound to the polymer P and containing at least one negative charge carried for example by sulfate groups, the polymer P being bound to hemoglobin on the one hand, through the intermediary of at least one linkage established between at least one of the Z sites contained in the polymer and hemoglobin, and, on the other, through the intermediary of at least one covalent linkage established between the polymer and hemoglobin, or between at least one of the Z sites contained in the polymer and hemoglobin. The macromolecular conjugates according to the invention exhibit a lower affinity for oxygen than that of free hemoglobin. |
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No. WO88/00055 PCT Pub. Date Jan. 14, 1988.The subject of the invention is a water-soluble macromolecular conjugate of hemoglobin characterized in that it is constituted on the one hand, by hemoglobin, on the other, by a water-soluble polymer P containing polar groups, this macromolecular conjugate contains Z sites, bound to the polymer P and containing at least one negative charge carried for example by sulfate groups, the polymer P being bound to hemoglobin on the one hand, through the intermediary of at least one linkage established between at least one of the Z sites contained in the polymer and hemoglobin, and, on the other, through the intermediary of at least one covalent linkage established between the polymer and hemoglobin, or between at least one of the Z sites contained in the polymer and hemoglobin. The macromolecular conjugates according to the invention exhibit a lower affinity for oxygen than that of free hemoglobin.</description><edition>5</edition><language>fre ; ger</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PEPTIDES ; POLYSACCHARIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19911015&DB=EPODOC&CC=AT&NR=E67673T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19911015&DB=EPODOC&CC=AT&NR=E67673T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEONARD, MICHELE</creatorcontrib><creatorcontrib>NEEL, JEAN MAURICE LEON</creatorcontrib><creatorcontrib>LABRUDE, PIERRE</creatorcontrib><creatorcontrib>VIGNERON, CLAUDE</creatorcontrib><creatorcontrib>SACCO, DANIEL</creatorcontrib><creatorcontrib>DELLACHERIE, EDITH</creatorcontrib><creatorcontrib>BONNEAUX, FRANCOIS</creatorcontrib><title>MAKROMOLEKULARE HAEMOGLOBINKONJUGATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNGEN</title><description>PCT No. PCT/FR87/00262 Sec. 371 Date Feb. 3, 1988 Sec. 102(e) Date Feb. 3, 1988 PCT Filed Jul. 2, 1987 PCT Pub. No. WO88/00055 PCT Pub. Date Jan. 14, 1988.The subject of the invention is a water-soluble macromolecular conjugate of hemoglobin characterized in that it is constituted on the one hand, by hemoglobin, on the other, by a water-soluble polymer P containing polar groups, this macromolecular conjugate contains Z sites, bound to the polymer P and containing at least one negative charge carried for example by sulfate groups, the polymer P being bound to hemoglobin on the one hand, through the intermediary of at least one linkage established between at least one of the Z sites contained in the polymer and hemoglobin, and, on the other, through the intermediary of at least one covalent linkage established between the polymer and hemoglobin, or between at least one of the Z sites contained in the polymer and hemoglobin. The macromolecular conjugates according to the invention exhibit a lower affinity for oxygen than that of free hemoglobin.</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PEPTIDES</subject><subject>POLYSACCHARIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIjydfQO8vf193H1DvVxDHJV8HB09fV39_F38vTz9vfzCnV3DHHVUQhzDXJz9Ahy9VOIClXwBDKCFDxcg4JDXH18Qv3cFUL9XMCiIHXhrn4uQDFXPx4G1rTEnOJUXijNzaDg5hri7KGbWpAfn1pckJicmpdaEg8038zczNw4JMTQmAglAFcqMp0</recordid><startdate>19911015</startdate><enddate>19911015</enddate><creator>LEONARD, MICHELE</creator><creator>NEEL, JEAN MAURICE LEON</creator><creator>LABRUDE, PIERRE</creator><creator>VIGNERON, CLAUDE</creator><creator>SACCO, DANIEL</creator><creator>DELLACHERIE, EDITH</creator><creator>BONNEAUX, FRANCOIS</creator><scope>EVB</scope></search><sort><creationdate>19911015</creationdate><title>MAKROMOLEKULARE HAEMOGLOBINKONJUGATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNGEN</title><author>LEONARD, MICHELE ; NEEL, JEAN MAURICE LEON ; LABRUDE, PIERRE ; VIGNERON, CLAUDE ; SACCO, DANIEL ; DELLACHERIE, EDITH ; BONNEAUX, FRANCOIS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ATE67673TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>fre ; ger</language><creationdate>1991</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PEPTIDES</topic><topic>POLYSACCHARIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>LEONARD, MICHELE</creatorcontrib><creatorcontrib>NEEL, JEAN MAURICE LEON</creatorcontrib><creatorcontrib>LABRUDE, PIERRE</creatorcontrib><creatorcontrib>VIGNERON, CLAUDE</creatorcontrib><creatorcontrib>SACCO, DANIEL</creatorcontrib><creatorcontrib>DELLACHERIE, EDITH</creatorcontrib><creatorcontrib>BONNEAUX, FRANCOIS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEONARD, MICHELE</au><au>NEEL, JEAN MAURICE LEON</au><au>LABRUDE, PIERRE</au><au>VIGNERON, CLAUDE</au><au>SACCO, DANIEL</au><au>DELLACHERIE, EDITH</au><au>BONNEAUX, FRANCOIS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MAKROMOLEKULARE HAEMOGLOBINKONJUGATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNGEN</title><date>1991-10-15</date><risdate>1991</risdate><abstract>PCT No. PCT/FR87/00262 Sec. 371 Date Feb. 3, 1988 Sec. 102(e) Date Feb. 3, 1988 PCT Filed Jul. 2, 1987 PCT Pub. No. WO88/00055 PCT Pub. Date Jan. 14, 1988.The subject of the invention is a water-soluble macromolecular conjugate of hemoglobin characterized in that it is constituted on the one hand, by hemoglobin, on the other, by a water-soluble polymer P containing polar groups, this macromolecular conjugate contains Z sites, bound to the polymer P and containing at least one negative charge carried for example by sulfate groups, the polymer P being bound to hemoglobin on the one hand, through the intermediary of at least one linkage established between at least one of the Z sites contained in the polymer and hemoglobin, and, on the other, through the intermediary of at least one covalent linkage established between the polymer and hemoglobin, or between at least one of the Z sites contained in the polymer and hemoglobin. The macromolecular conjugates according to the invention exhibit a lower affinity for oxygen than that of free hemoglobin.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PEPTIDES POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | MAKROMOLEKULARE HAEMOGLOBINKONJUGATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNGEN |
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