POLYMORPHIN VON 5-Ä4-ÄÄ3-METHYL-4-OXO-3,4- DIHYDROCHINAZOLIN-2-YLÜMETHOXYÜBENZYLÜ THIAZOLIDIN-2,4-DION KALIUM SALZ

A process for preparing polymorphic Form I of 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]methoxy]benzyl]thiazolidine-2,4-dione potassium salt having the formula: and characterized by having a differential scanning calorimetry curve with endotherms at 301.17 and 311.82°C and an exotherm at 297....

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Bibliographische Detailangaben
Hauptverfasser:	GADDAM, OM REDDY, POTLAPALLY, RAJENDER KUMAR, SRISILLA, RAJU, MAMILLAPALLI, RAMABHADRA S
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING
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Zusammenfassung:	A process for preparing polymorphic Form I of 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]methoxy]benzyl]thiazolidine-2,4-dione potassium salt having the formula: and characterized by having a differential scanning calorimetry curve with endotherms at 301.17 and 311.82°C and an exotherm at 297.68°C, comprising: (i) dissolving 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]methoxy]benzyl]thiazolidine-2,4-dione in an organic solvent at 60-80°C; (ii) adding a solution of potassium tertiary butoxide, at 40-60°C; (iii) stirring at a temperature of 20-90°C; and (iv) cooling, separating a precipitate and drying under vacuum at 40-70°C.