PER-6-GUANIDINO-, -AMINOALKYLAMINO- UND - GUANIDINO-ALKYLAMINO-CYCLODEXTRINE, VERFAHREN ZU IHRER SYNTHESE UND IHRE VERWENDUNG ZUR KOMPAKTIERUNG VON DNA UND INTERAZELLULÄREN ZUFÜHRUNG

PER-6-GUANIDINO-, -AMINOALKYLAMINO- UND - GUANIDINO-ALKYLAMINO-CYCLODEXTRINE, VERFAHREN ZU IHRER SYNTHESE UND IHRE VERWENDUNG ZUR KOMPAKTIERUNG VON DNA UND INTERAZELLULÄREN ZUFÜHRUNG

The invention relates to new compounds of type hexakis(6-deoxy-6-NH(CH2)n-R1)α-cyclodextrin and heptakis(6-deoxy-6-NH(CH2)n-R1)-( -cyclodextrin, and octakis(6-deoxy-6-NH(CH2)n-R1)-γ-cyclodextrin, where n=2-6 when R1=NH2 and n=0 when R1=C( NH)NH2 and n=2-6 when R1=NH-C( NH)NH2 and their use in the co...

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Hauptverfasser: AGGELIDOU, CHRYSI, MAVRIDIS, IRENE M, ELIADOU, KYRIAKI, YANNAKOPOULOU, KONSTANTINA, MOURTZIS, NIKOLAOS
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creator AGGELIDOU, CHRYSI
MAVRIDIS, IRENE M
ELIADOU, KYRIAKI
YANNAKOPOULOU, KONSTANTINA
MOURTZIS, NIKOLAOS
description The invention relates to new compounds of type hexakis(6-deoxy-6-NH(CH2)n-R1)α-cyclodextrin and heptakis(6-deoxy-6-NH(CH2)n-R1)-( -cyclodextrin, and octakis(6-deoxy-6-NH(CH2)n-R1)-γ-cyclodextrin, where n=2-6 when R1=NH2 and n=0 when R1=C( NH)NH2 and n=2-6 when R1=NH-C( NH)NH2 and their use in the compaction of DNA and in cell permeation. The invention also relates to methods of synthesis of the above compounds.
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title PER-6-GUANIDINO-, -AMINOALKYLAMINO- UND - GUANIDINO-ALKYLAMINO-CYCLODEXTRINE, VERFAHREN ZU IHRER SYNTHESE UND IHRE VERWENDUNG ZUR KOMPAKTIERUNG VON DNA UND INTERAZELLULÄREN ZUFÜHRUNG
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