REKOMBINANTE BCG-STÄMME MIT VERBESSERTER FÄHIGKEIT ZUM ENTWEICHEN AUS DEM ENDOSOM

REKOMBINANTE BCG-STÄMME MIT VERBESSERTER FÄHIGKEIT ZUM ENTWEICHEN AUS DEM ENDOSOM

Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Myc...

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Hauptverfasser: HONE, DAVID, SADOFF, JERALD, SUN, RONGGAI
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SADOFF, JERALD
SUN, RONGGAI
description Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains.
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title REKOMBINANTE BCG-STÄMME MIT VERBESSERTER FÄHIGKEIT ZUM ENTWEICHEN AUS DEM ENDOSOM
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