DURCH 5GLIEDRIGE HETEROCYCLEN SUBSTITUIERTE MTP- INHIBIERENDE ARYLPIPERIDINE ODER -PIPERAZINE

DURCH 5GLIEDRIGE HETEROCYCLEN SUBSTITUIERTE MTP- INHIBIERENDE ARYLPIPERIDINE ODER -PIPERAZINE

The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmac...

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Hauptverfasser: JAROSKOVA, LIBUSE, LINDERS, JOANNES T.M, ROEVENS, PETER W.M, VAN DER VEKEN, L. J.E, VIELLEVOYE, MARCEL, MEERPOEL, LIEVEN, BACKX, LEO JACOBUS J
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator JAROSKOVA, LIBUSE
LINDERS, JOANNES T.M
ROEVENS, PETER W.M
VAN DER VEKEN, L. J.E
VIELLEVOYE, MARCEL
MEERPOEL, LIEVEN
BACKX, LEO JACOBUS J
description The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title DURCH 5GLIEDRIGE HETEROCYCLEN SUBSTITUIERTE MTP- INHIBIERENDE ARYLPIPERIDINE ODER -PIPERAZINE
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