VERFAHREN ZUR HERSTELLUNG VON PYRIMIDIN-5- CARBOXYLATEN

VERFAHREN ZUR HERSTELLUNG VON PYRIMIDIN-5- CARBOXYLATEN

Pyrimidine-5-carboxylates of formula: wherein R is C1-4 alkyl, R1 is C1-4 alkyl, trifluoromethyl, R2 is hydrogen or C1-4 alkyl and X is hydroxy, chlorine or bromine, are prepared from certain 3-oxoalkanoates of formula (II): with urea and orthoesters of formula (III) R2C(OR). The intermediate 2-acyl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: RITTINER, BRUNO, DUCRY, LAURENT
Format: Patent
Sprache:ger
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator RITTINER, BRUNO
DUCRY, LAURENT
description Pyrimidine-5-carboxylates of formula: wherein R is C1-4 alkyl, R1 is C1-4 alkyl, trifluoromethyl, R2 is hydrogen or C1-4 alkyl and X is hydroxy, chlorine or bromine, are prepared from certain 3-oxoalkanoates of formula (II): with urea and orthoesters of formula (III) R2C(OR). The intermediate 2-acyl-3-ureidoacrylate, without being isolated, is reacted to give a 2-hydroxypyrimidine-5-carboxylate[(I), X-OH] or a hydrate thereof, which is optionally converted into the corresponding chloro or bromo compound (I, X-Cl, Br).
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ATE392417TT1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ATE392417TT1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ATE392417TT13</originalsourceid><addsrcrecordid>eNrjZDAPcw1yc_QIcvVTiAoNUvBwDQoOcfXxCfVzVwjz91MIiAzy9PV08fTTNdVVcHYMcvKPiPRxDHH142FgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8UClxpZGJobmISGGxsSoAQBqVSkG</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>VERFAHREN ZUR HERSTELLUNG VON PYRIMIDIN-5- CARBOXYLATEN</title><source>esp@cenet</source><creator>RITTINER, BRUNO ; DUCRY, LAURENT</creator><creatorcontrib>RITTINER, BRUNO ; DUCRY, LAURENT</creatorcontrib><description>Pyrimidine-5-carboxylates of formula: wherein R is C1-4 alkyl, R1 is C1-4 alkyl, trifluoromethyl, R2 is hydrogen or C1-4 alkyl and X is hydroxy, chlorine or bromine, are prepared from certain 3-oxoalkanoates of formula (II): with urea and orthoesters of formula (III) R2C(OR). The intermediate 2-acyl-3-ureidoacrylate, without being isolated, is reacted to give a 2-hydroxypyrimidine-5-carboxylate[(I), X-OH] or a hydrate thereof, which is optionally converted into the corresponding chloro or bromo compound (I, X-Cl, Br).</description><language>ger</language><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20080515&amp;DB=EPODOC&amp;CC=AT&amp;NR=E392417T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20080515&amp;DB=EPODOC&amp;CC=AT&amp;NR=E392417T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RITTINER, BRUNO</creatorcontrib><creatorcontrib>DUCRY, LAURENT</creatorcontrib><title>VERFAHREN ZUR HERSTELLUNG VON PYRIMIDIN-5- CARBOXYLATEN</title><description>Pyrimidine-5-carboxylates of formula: wherein R is C1-4 alkyl, R1 is C1-4 alkyl, trifluoromethyl, R2 is hydrogen or C1-4 alkyl and X is hydroxy, chlorine or bromine, are prepared from certain 3-oxoalkanoates of formula (II): with urea and orthoesters of formula (III) R2C(OR). The intermediate 2-acyl-3-ureidoacrylate, without being isolated, is reacted to give a 2-hydroxypyrimidine-5-carboxylate[(I), X-OH] or a hydrate thereof, which is optionally converted into the corresponding chloro or bromo compound (I, X-Cl, Br).</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAPcw1yc_QIcvVTiAoNUvBwDQoOcfXxCfVzVwjz91MIiAzy9PV08fTTNdVVcHYMcvKPiPRxDHH142FgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8UClxpZGJobmISGGxsSoAQBqVSkG</recordid><startdate>20080515</startdate><enddate>20080515</enddate><creator>RITTINER, BRUNO</creator><creator>DUCRY, LAURENT</creator><scope>EVB</scope></search><sort><creationdate>20080515</creationdate><title>VERFAHREN ZUR HERSTELLUNG VON PYRIMIDIN-5- CARBOXYLATEN</title><author>RITTINER, BRUNO ; DUCRY, LAURENT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ATE392417TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>2008</creationdate><toplevel>online_resources</toplevel><creatorcontrib>RITTINER, BRUNO</creatorcontrib><creatorcontrib>DUCRY, LAURENT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RITTINER, BRUNO</au><au>DUCRY, LAURENT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VERFAHREN ZUR HERSTELLUNG VON PYRIMIDIN-5- CARBOXYLATEN</title><date>2008-05-15</date><risdate>2008</risdate><abstract>Pyrimidine-5-carboxylates of formula: wherein R is C1-4 alkyl, R1 is C1-4 alkyl, trifluoromethyl, R2 is hydrogen or C1-4 alkyl and X is hydroxy, chlorine or bromine, are prepared from certain 3-oxoalkanoates of formula (II): with urea and orthoesters of formula (III) R2C(OR). The intermediate 2-acyl-3-ureidoacrylate, without being isolated, is reacted to give a 2-hydroxypyrimidine-5-carboxylate[(I), X-OH] or a hydrate thereof, which is optionally converted into the corresponding chloro or bromo compound (I, X-Cl, Br).</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language ger
recordid cdi_epo_espacenet_ATE392417TT1
source esp@cenet
title VERFAHREN ZUR HERSTELLUNG VON PYRIMIDIN-5- CARBOXYLATEN
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T20%3A09%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=RITTINER,%20BRUNO&rft.date=2008-05-15&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EATE392417TT1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true