PARTIKULÄRE ZUSAMMENSETZUNG MIT SIGMOIDEM FREISETZUNGSMUSTER ENTHALTEND ELETRIPTAN HYDROBROMID

PARTIKULÄRE ZUSAMMENSETZUNG MIT SIGMOIDEM FREISETZUNGSMUSTER ENTHALTEND ELETRIPTAN HYDROBROMID

The invention provides a pharmaceutical composition in particulate form, suitable for oral administration, including a core containing eletriptan or a pharmaceutically acceptable salt thereof, the core being coated with a water-insoluble, permeable coating including one or more acrylic copolymer(s)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MACRAE, ROSS J, WALTHER, MATHIAS, DE RASPIDE, MANAUD
Format: Patent
Sprache:ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides a pharmaceutical composition in particulate form, suitable for oral administration, including a core containing eletriptan or a pharmaceutically acceptable salt thereof, the core being coated with a water-insoluble, permeable coating including one or more acrylic copolymer(s) containing trimethylammoniumethylmethacrylate groups, said composition being capable of achieving a sigmoidal pattern of controlled drug release. Such a pharmaceutical composition is particularly useful in the prevention of migraine recurrence.