VERFAHREN ZUR HERSTELLUNG VOM MESYLAT SALZ DES TRIHYDRATS DES 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERI IN-1-YL)-1-PROPANOLS UND ZWISCHENPRODUKTE FÜR DIESES VERFAHREN

VERFAHREN ZUR HERSTELLUNG VOM MESYLAT SALZ DES TRIHYDRATS DES 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERI IN-1-YL)-1-PROPANOLS UND ZWISCHENPRODUKTE FÜR DIESES VERFAHREN

The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-pro panol: The present invention is further directed to a process for the preparation of a (2S)-(+)-c...

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Bibliographische Detailangaben
Hauptverfasser: SINAY, TERRY GENE, JR, WALINSKY, STANLEY WALTER, RAINVILLE, JOSEPH PHILIP
Format: Patent
Sprache:ger
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-pro panol: The present invention is further directed to a process for the preparation of a (2S)-(+)-compound of formula (II): wherein R is a protecting group. In addition, the present invention relates to intermediates useful in said processes.