ZWISCHENPRODUKTE FÜR DIE SYNTHESE VON VITAMIN D

The invention relates to an improved process for preparing Ä(3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dioneÜ. (S)-(+)-2,3,7,7a-tetrahydro-7a-methyl-1H-indene-1,5(6H)-dione is reduced by reaction with diisobutylaluminum hydride and hexamethylphosphoric triaminde in the presence of a catal...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
1. Verfasser:	DANIEWSKI, ANDRZEJ ROBERT
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	DANIEWSKI, ANDRZEJ ROBERT
description	The invention relates to an improved process for preparing Ä(3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dioneÜ. (S)-(+)-2,3,7,7a-tetrahydro-7a-methyl-1H-indene-1,5(6H)-dione is reduced by reaction with diisobutylaluminum hydride and hexamethylphosphoric triaminde in the presence of a catalyst of the formula R-Cu, wherein R is and R , R and R are each, independently, selected from the group consisting of C1-7 alkyl, phenyl, phenyl substituted by at least one C1-4 alkyl group, benzyl, or benzyl substituted by at least one C1-4 alkyl groups to form a reductate. The reductate is then treated with a bromine-containing electrophile to yield (3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dione.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ATE238262TT1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ATE238262TT1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ATE238262TT13</originalsourceid><addsrcrecordid>eNrjZDCICvcMdvZw9QsI8ncJ9Q5xVXA7PCdIwcXTVSE40i_EwzXYVSHM308hzDPE0dfTT8GFh4E1LTGnOJUXSnMzKLq5hjh76KYW5MenFhckJqfmpZbEO4a4GhlbGJkZhYQYGhOjBgCzZSfL</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ZWISCHENPRODUKTE FÜR DIE SYNTHESE VON VITAMIN D</title><source>esp@cenet</source><creator>DANIEWSKI, ANDRZEJ ROBERT</creator><creatorcontrib>DANIEWSKI, ANDRZEJ ROBERT</creatorcontrib><description>The invention relates to an improved process for preparing Ä(3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dioneÜ. (S)-(+)-2,3,7,7a-tetrahydro-7a-methyl-1H-indene-1,5(6H)-dione is reduced by reaction with diisobutylaluminum hydride and hexamethylphosphoric triaminde in the presence of a catalyst of the formula R-Cu, wherein R is and R , R and R are each, independently, selected from the group consisting of C1-7 alkyl, phenyl, phenyl substituted by at least one C1-4 alkyl group, benzyl, or benzyl substituted by at least one C1-4 alkyl groups to form a reductate. The reductate is then treated with a bromine-containing electrophile to yield (3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dione.</description><edition>7</edition><language>ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030515&DB=EPODOC&CC=AT&NR=E238262T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030515&DB=EPODOC&CC=AT&NR=E238262T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DANIEWSKI, ANDRZEJ ROBERT</creatorcontrib><title>ZWISCHENPRODUKTE FÜR DIE SYNTHESE VON VITAMIN D</title><description>The invention relates to an improved process for preparing Ä(3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dioneÜ. (S)-(+)-2,3,7,7a-tetrahydro-7a-methyl-1H-indene-1,5(6H)-dione is reduced by reaction with diisobutylaluminum hydride and hexamethylphosphoric triaminde in the presence of a catalyst of the formula R-Cu, wherein R is and R , R and R are each, independently, selected from the group consisting of C1-7 alkyl, phenyl, phenyl substituted by at least one C1-4 alkyl group, benzyl, or benzyl substituted by at least one C1-4 alkyl groups to form a reductate. The reductate is then treated with a bromine-containing electrophile to yield (3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dione.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDCICvcMdvZw9QsI8ncJ9Q5xVXA7PCdIwcXTVSE40i_EwzXYVSHM308hzDPE0dfTT8GFh4E1LTGnOJUXSnMzKLq5hjh76KYW5MenFhckJqfmpZbEO4a4GhlbGJkZhYQYGhOjBgCzZSfL</recordid><startdate>20030515</startdate><enddate>20030515</enddate><creator>DANIEWSKI, ANDRZEJ ROBERT</creator><scope>EVB</scope></search><sort><creationdate>20030515</creationdate><title>ZWISCHENPRODUKTE FÜR DIE SYNTHESE VON VITAMIN D</title><author>DANIEWSKI, ANDRZEJ ROBERT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ATE238262TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>2003</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>DANIEWSKI, ANDRZEJ ROBERT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DANIEWSKI, ANDRZEJ ROBERT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ZWISCHENPRODUKTE FÜR DIE SYNTHESE VON VITAMIN D</title><date>2003-05-15</date><risdate>2003</risdate><abstract>The invention relates to an improved process for preparing Ä(3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dioneÜ. (S)-(+)-2,3,7,7a-tetrahydro-7a-methyl-1H-indene-1,5(6H)-dione is reduced by reaction with diisobutylaluminum hydride and hexamethylphosphoric triaminde in the presence of a catalyst of the formula R-Cu, wherein R is and R , R and R are each, independently, selected from the group consisting of C1-7 alkyl, phenyl, phenyl substituted by at least one C1-4 alkyl group, benzyl, or benzyl substituted by at least one C1-4 alkyl groups to form a reductate. The reductate is then treated with a bromine-containing electrophile to yield (3aR,4S,7aS)-4-bromooctahydro-7a-methyl-1H-indene-1,5-dione.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	ger
recordid	cdi_epo_espacenet_ATE238262TT1
source	esp@cenet
subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
title	ZWISCHENPRODUKTE FÜR DIE SYNTHESE VON VITAMIN D
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T19%3A49%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=DANIEWSKI,%20ANDRZEJ%20ROBERT&rft.date=2003-05-15&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EATE238262TT1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true