VERFAHREN UND ZWISCHENPRODUKTE ZUR HERSTELLUNG VON AMLODIPIN-BENZOLSULFONAT

VERFAHREN UND ZWISCHENPRODUKTE ZUR HERSTELLUNG VON AMLODIPIN-BENZOLSULFONAT

A subject matter of the invention is a process for preparing 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(aminoethoxy)-methylÜ-4--Ä2''-(chloro)-phen ylÜ-6-ÄmethylÜ-1,4-di-ÄhydroÜ-pyridine-3,5-di-ÄcarboxylateÜ benzenesulfonic acid salt of Formula in which 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(yl)-ethoxy-met...

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Hauptverfasser: TOEMPE, PETER, SIMIG, GYULA, BOZSING, DANIEL, NEMETH, NORBERT, KOVANYI, GYOERGYI, LAX, KRASZNAI, GYOERGY, NAGY, KALMAN, NEMET, GABOR, BLASKO, GABOR, VERECZKEY, GYOERGYI DONATH
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creator TOEMPE, PETER
SIMIG, GYULA
BOZSING, DANIEL
NEMETH, NORBERT
KOVANYI, GYOERGYI, LAX
KRASZNAI, GYOERGY
NAGY, KALMAN
NEMET, GABOR
BLASKO, GABOR
VERECZKEY, GYOERGYI DONATH
description A subject matter of the invention is a process for preparing 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(aminoethoxy)-methylÜ-4--Ä2''-(chloro)-phen ylÜ-6-ÄmethylÜ-1,4-di-ÄhydroÜ-pyridine-3,5-di-ÄcarboxylateÜ benzenesulfonic acid salt of Formula in which 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(yl)-ethoxy-methylÜ-4-Ä2''-(chloro)-phenylÜ -6-ÄmethylÜ-1,4-di-ÄhydroÜ-pyridine-3,5-di-ÄcarboxylateÜ hexaminium iodide of Formula is reacted with benzenesulfonic acid of Formula Several variants comprise also reactions for preparing intermediates leading to the said end product. A further subject matter of the invention are intermediates for preparing the said end product.
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title VERFAHREN UND ZWISCHENPRODUKTE ZUR HERSTELLUNG VON AMLODIPIN-BENZOLSULFONAT
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