PHENYLGLYCIDAT-STEREOISOMERE, UMSETZUNGSPRODUKTE MIT 2-NITROTHIOPHENOL UND HERSTELLUNG VON DILTIAZEN
The stereoisomerically pure esters of (2R,3S)-3-(4-hydroxy or 4-alkoxyphenyl)glycidic acid, which is a starting compound for the preparation of diltiazem, are prepared by stereospecific enzymatic hydrolysis. By using such an ester, it is possible to economically prepare the (2S,3S) isomer of diltiaz...
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| creator | ROSKAM, JAN HENDRIK HULSHOF, LUMBERTUS ALBREGT |
| description | The stereoisomerically pure esters of (2R,3S)-3-(4-hydroxy or 4-alkoxyphenyl)glycidic acid, which is a starting compound for the preparation of diltiazem, are prepared by stereospecific enzymatic hydrolysis. By using such an ester, it is possible to economically prepare the (2S,3S) isomer of diltiazem to the exclusion of other stereoisomers. |
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By using such an ester, it is possible to economically prepare the (2S,3S) isomer of diltiazem to the exclusion of other stereoisomers.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE |
| title | PHENYLGLYCIDAT-STEREOISOMERE, UMSETZUNGSPRODUKTE MIT 2-NITROTHIOPHENOL UND HERSTELLUNG VON DILTIAZEN |
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