1-OXA-2-OXO-8-AZASPIRO(4,5>DECAN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DARAUS
The invention relates to 2-oxo-1-oxa-8-azaspiro [4,5] decane derivatives of formula (I), wherein X represents an oxygen atom or a NR group, wherein R represents a hydrogen atom or a C1-12 alkyl or C3-6cycloalkyl group, or a carbocyclic C6-10aryl or carbocylic C6-10aryl-C1-4alkyl group optionally sub...
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| creator | TOTH, EDIT TOERLEY, JOZSEF SARKADI, ADAM SZPORNY, LASZLO KISS, BELA LASZY, JUDIT LASZLOVSZKY, ISTVAN HEGEDUES, BELA GROO, DORA LAPIS, ERZSEBET PALOSI, EVA AMBRUS ANDRAS |
| description | The invention relates to 2-oxo-1-oxa-8-azaspiro [4,5] decane derivatives of formula (I), wherein X represents an oxygen atom or a NR group, wherein R represents a hydrogen atom or a C1-12 alkyl or C3-6cycloalkyl group, or a carbocyclic C6-10aryl or carbocylic C6-10aryl-C1-4alkyl group optionally substituted on the aromatic ring by one or more halogen atoms, C1-4 alkyl or C1-4alkoxy groups; R and R together represent a methylene group or when X is a >NR group, one of R and R may additionally represent a hydroxyl group and the other represent a methyl group; Z represents a hydrogen or halogen atom or a trihalomethyl or a C2-4alkanoyl group; and n is 2 or 3; and all optical isomers and mixtures thereof and all acid addition and quarternary ammonium salts thereof. The invention further relates to pharmaceutical compositions containing these compounds and processes for their preparation. The compounds of formula (I) possess psychotropic and antiallergic properties and a low toxicity. Thus, they may be useful for the treatment of psychiatric and allergic diseases. |
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The invention further relates to pharmaceutical compositions containing these compounds and processes for their preparation. The compounds of formula (I) possess psychotropic and antiallergic properties and a low toxicity. Thus, they may be useful for the treatment of psychiatric and allergic diseases.</description><edition>5</edition><language>eng ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940415&DB=EPODOC&CC=AT&NR=E103921T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940415&DB=EPODOC&CC=AT&NR=E103921T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TOTH, EDIT</creatorcontrib><creatorcontrib>TOERLEY, JOZSEF</creatorcontrib><creatorcontrib>SARKADI, ADAM</creatorcontrib><creatorcontrib>SZPORNY, LASZLO</creatorcontrib><creatorcontrib>KISS, BELA</creatorcontrib><creatorcontrib>LASZY, JUDIT</creatorcontrib><creatorcontrib>LASZLOVSZKY, ISTVAN</creatorcontrib><creatorcontrib>HEGEDUES, BELA</creatorcontrib><creatorcontrib>GROO, DORA</creatorcontrib><creatorcontrib>LAPIS, ERZSEBET</creatorcontrib><creatorcontrib>PALOSI, EVA</creatorcontrib><creatorcontrib>AMBRUS ANDRAS</creatorcontrib><title>1-OXA-2-OXO-8-AZASPIRO(4,5>DECAN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DARAUS</title><description>The invention relates to 2-oxo-1-oxa-8-azaspiro [4,5] decane derivatives of formula (I), wherein X represents an oxygen atom or a NR group, wherein R represents a hydrogen atom or a C1-12 alkyl or C3-6cycloalkyl group, or a carbocyclic C6-10aryl or carbocylic C6-10aryl-C1-4alkyl group optionally substituted on the aromatic ring by one or more halogen atoms, C1-4 alkyl or C1-4alkoxy groups; R and R together represent a methylene group or when X is a >NR group, one of R and R may additionally represent a hydroxyl group and the other represent a methyl group; Z represents a hydrogen or halogen atom or a trihalomethyl or a C2-4alkanoyl group; and n is 2 or 3; and all optical isomers and mixtures thereof and all acid addition and quarternary ammonium salts thereof. The invention further relates to pharmaceutical compositions containing these compounds and processes for their preparation. The compounds of formula (I) possess psychotropic and antiallergic properties and a low toxicity. Thus, they may be useful for the treatment of psychiatric and allergic diseases.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjbEKwjAURbs4iPoPcXNowFYFXYRH82oCbVpekiJZSpE4iRYqfr8Z_ACXe-5wLneefDLeXIHnMRt-5ODBtIqazT49nAUWoLlAUh1YTFmHVIIk1Mw7pmIhJpGMxapy-sKcFqyVQDV4dFaZQmIUDdQ1aoPWRydOBRA4s0xm9-ExhdWPi2Rdoi0kD-OrD9M43MIzvPt4m213pzyzNtv943wBBME6Aw</recordid><startdate>19940415</startdate><enddate>19940415</enddate><creator>TOTH, EDIT</creator><creator>TOERLEY, JOZSEF</creator><creator>SARKADI, ADAM</creator><creator>SZPORNY, LASZLO</creator><creator>KISS, BELA</creator><creator>LASZY, JUDIT</creator><creator>LASZLOVSZKY, ISTVAN</creator><creator>HEGEDUES, BELA</creator><creator>GROO, DORA</creator><creator>LAPIS, ERZSEBET</creator><creator>PALOSI, EVA</creator><creator>AMBRUS ANDRAS</creator><scope>EVB</scope></search><sort><creationdate>19940415</creationdate><title>1-OXA-2-OXO-8-AZASPIRO(4,5>DECAN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DARAUS</title><author>TOTH, EDIT ; TOERLEY, JOZSEF ; SARKADI, ADAM ; SZPORNY, LASZLO ; KISS, BELA ; LASZY, JUDIT ; LASZLOVSZKY, ISTVAN ; HEGEDUES, BELA ; GROO, DORA ; LAPIS, ERZSEBET ; PALOSI, EVA ; AMBRUS ANDRAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ATE103921TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>1994</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TOTH, EDIT</creatorcontrib><creatorcontrib>TOERLEY, JOZSEF</creatorcontrib><creatorcontrib>SARKADI, ADAM</creatorcontrib><creatorcontrib>SZPORNY, LASZLO</creatorcontrib><creatorcontrib>KISS, BELA</creatorcontrib><creatorcontrib>LASZY, JUDIT</creatorcontrib><creatorcontrib>LASZLOVSZKY, ISTVAN</creatorcontrib><creatorcontrib>HEGEDUES, BELA</creatorcontrib><creatorcontrib>GROO, DORA</creatorcontrib><creatorcontrib>LAPIS, ERZSEBET</creatorcontrib><creatorcontrib>PALOSI, EVA</creatorcontrib><creatorcontrib>AMBRUS ANDRAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TOTH, EDIT</au><au>TOERLEY, JOZSEF</au><au>SARKADI, ADAM</au><au>SZPORNY, LASZLO</au><au>KISS, BELA</au><au>LASZY, JUDIT</au><au>LASZLOVSZKY, ISTVAN</au><au>HEGEDUES, BELA</au><au>GROO, DORA</au><au>LAPIS, ERZSEBET</au><au>PALOSI, EVA</au><au>AMBRUS ANDRAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>1-OXA-2-OXO-8-AZASPIRO(4,5>DECAN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DARAUS</title><date>1994-04-15</date><risdate>1994</risdate><abstract>The invention relates to 2-oxo-1-oxa-8-azaspiro [4,5] decane derivatives of formula (I), wherein X represents an oxygen atom or a NR group, wherein R represents a hydrogen atom or a C1-12 alkyl or C3-6cycloalkyl group, or a carbocyclic C6-10aryl or carbocylic C6-10aryl-C1-4alkyl group optionally substituted on the aromatic ring by one or more halogen atoms, C1-4 alkyl or C1-4alkoxy groups; R and R together represent a methylene group or when X is a >NR group, one of R and R may additionally represent a hydroxyl group and the other represent a methyl group; Z represents a hydrogen or halogen atom or a trihalomethyl or a C2-4alkanoyl group; and n is 2 or 3; and all optical isomers and mixtures thereof and all acid addition and quarternary ammonium salts thereof. The invention further relates to pharmaceutical compositions containing these compounds and processes for their preparation. The compounds of formula (I) possess psychotropic and antiallergic properties and a low toxicity. Thus, they may be useful for the treatment of psychiatric and allergic diseases.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 1-OXA-2-OXO-8-AZASPIRO(4,5>DECAN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DARAUS |
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