APPARATUS FOR PRODUCING SCAFFOLDING
The invention relates to new halovincamone derivatives of the general formula (I), (I) wherein R is a C1-6 alkyl group and X is halogen, and pharmaceutically acceptable acid addition salts and optically active isomers thereof. These compounds possess valuable vasodilating effect, and can be applied...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KEVE TIBOR DR SZABO LAJOS DR DANCSI LAJOS SZANTAY CSABA DR KALAUS GYOERGY DR DREXLER FERENC |
| description | The invention relates to new halovincamone derivatives of the general formula (I), (I) wherein R is a C1-6 alkyl group and X is halogen, and pharmaceutically acceptable acid addition salts and optically active isomers thereof. These compounds possess valuable vasodilating effect, and can be applied to advantage in the therapy. The new compounds defined above are prepared according to the invention so that a single epimer or an epimeric mixture of a racemic or optically active halogenated 14-oxo-15-hydroxy-E-homoeburnane derivative of the general formula (II), (II) wherein R and X are as defined above, or an acid addition salt thereof is treated with an oxidizing agent, and, if desired, the resulting compound of the general formula (I) is converted into its pharmaceutically acceptable acid addition salt and/or resolved. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ATA396380A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ATA396380A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ATA396380A3</originalsourceid><addsrcrecordid>eNrjZFB2DAhwDHIMCQ1WcPMPUggI8ncJdfb0c1cIdnZ0c_P3cQGyeRhY0xJzilN5oTQ3g7yba4izh25qQX58anFBYnJqXmpJvGOIo7GlmbGFgaMxYRUA5VMiLQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>APPARATUS FOR PRODUCING SCAFFOLDING</title><source>esp@cenet</source><creator>KEVE TIBOR DR ; SZABO LAJOS DR ; DANCSI LAJOS ; SZANTAY CSABA DR ; KALAUS GYOERGY DR ; DREXLER FERENC</creator><creatorcontrib>KEVE TIBOR DR ; SZABO LAJOS DR ; DANCSI LAJOS ; SZANTAY CSABA DR ; KALAUS GYOERGY DR ; DREXLER FERENC</creatorcontrib><description>The invention relates to new halovincamone derivatives of the general formula (I), (I) wherein R is a C1-6 alkyl group and X is halogen, and pharmaceutically acceptable acid addition salts and optically active isomers thereof. These compounds possess valuable vasodilating effect, and can be applied to advantage in the therapy. The new compounds defined above are prepared according to the invention so that a single epimer or an epimeric mixture of a racemic or optically active halogenated 14-oxo-15-hydroxy-E-homoeburnane derivative of the general formula (II), (II) wherein R and X are as defined above, or an acid addition salt thereof is treated with an oxidizing agent, and, if desired, the resulting compound of the general formula (I) is converted into its pharmaceutically acceptable acid addition salt and/or resolved.</description><edition>3</edition><language>eng ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1983</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19830815&DB=EPODOC&CC=AT&NR=A396380A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19830815&DB=EPODOC&CC=AT&NR=A396380A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KEVE TIBOR DR</creatorcontrib><creatorcontrib>SZABO LAJOS DR</creatorcontrib><creatorcontrib>DANCSI LAJOS</creatorcontrib><creatorcontrib>SZANTAY CSABA DR</creatorcontrib><creatorcontrib>KALAUS GYOERGY DR</creatorcontrib><creatorcontrib>DREXLER FERENC</creatorcontrib><title>APPARATUS FOR PRODUCING SCAFFOLDING</title><description>The invention relates to new halovincamone derivatives of the general formula (I), (I) wherein R is a C1-6 alkyl group and X is halogen, and pharmaceutically acceptable acid addition salts and optically active isomers thereof. These compounds possess valuable vasodilating effect, and can be applied to advantage in the therapy. The new compounds defined above are prepared according to the invention so that a single epimer or an epimeric mixture of a racemic or optically active halogenated 14-oxo-15-hydroxy-E-homoeburnane derivative of the general formula (II), (II) wherein R and X are as defined above, or an acid addition salt thereof is treated with an oxidizing agent, and, if desired, the resulting compound of the general formula (I) is converted into its pharmaceutically acceptable acid addition salt and/or resolved.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1983</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB2DAhwDHIMCQ1WcPMPUggI8ncJdfb0c1cIdnZ0c_P3cQGyeRhY0xJzilN5oTQ3g7yba4izh25qQX58anFBYnJqXmpJvGOIo7GlmbGFgaMxYRUA5VMiLQ</recordid><startdate>19830815</startdate><enddate>19830815</enddate><creator>KEVE TIBOR DR</creator><creator>SZABO LAJOS DR</creator><creator>DANCSI LAJOS</creator><creator>SZANTAY CSABA DR</creator><creator>KALAUS GYOERGY DR</creator><creator>DREXLER FERENC</creator><scope>EVB</scope></search><sort><creationdate>19830815</creationdate><title>APPARATUS FOR PRODUCING SCAFFOLDING</title><author>KEVE TIBOR DR ; SZABO LAJOS DR ; DANCSI LAJOS ; SZANTAY CSABA DR ; KALAUS GYOERGY DR ; DREXLER FERENC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ATA396380A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>1983</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KEVE TIBOR DR</creatorcontrib><creatorcontrib>SZABO LAJOS DR</creatorcontrib><creatorcontrib>DANCSI LAJOS</creatorcontrib><creatorcontrib>SZANTAY CSABA DR</creatorcontrib><creatorcontrib>KALAUS GYOERGY DR</creatorcontrib><creatorcontrib>DREXLER FERENC</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KEVE TIBOR DR</au><au>SZABO LAJOS DR</au><au>DANCSI LAJOS</au><au>SZANTAY CSABA DR</au><au>KALAUS GYOERGY DR</au><au>DREXLER FERENC</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>APPARATUS FOR PRODUCING SCAFFOLDING</title><date>1983-08-15</date><risdate>1983</risdate><abstract>The invention relates to new halovincamone derivatives of the general formula (I), (I) wherein R is a C1-6 alkyl group and X is halogen, and pharmaceutically acceptable acid addition salts and optically active isomers thereof. These compounds possess valuable vasodilating effect, and can be applied to advantage in the therapy. The new compounds defined above are prepared according to the invention so that a single epimer or an epimeric mixture of a racemic or optically active halogenated 14-oxo-15-hydroxy-E-homoeburnane derivative of the general formula (II), (II) wherein R and X are as defined above, or an acid addition salt thereof is treated with an oxidizing agent, and, if desired, the resulting compound of the general formula (I) is converted into its pharmaceutically acceptable acid addition salt and/or resolved.</abstract><edition>3</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; ger |
| recordid | cdi_epo_espacenet_ATA396380A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | APPARATUS FOR PRODUCING SCAFFOLDING |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T12%3A21%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KEVE%20TIBOR%20DR&rft.date=1983-08-15&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EATA396380A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |