PROCESS FOR THE PREPARATION OF 1-SUBST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, NOVEL INTERMEDIATE FOR USE IN THIS PROCESS AND PROCESS FOR THE PREPARATION OF THIS INTERMEDIATE

PROCESS FOR THE PREPARATION OF 1-SUBST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, NOVEL INTERMEDIATE FOR USE IN THIS PROCESS AND PROCESS FOR THE PREPARATION OF THIS INTERMEDIATE

A process for the preparation of 1-subst.-6-fluoro-4-oxo- 7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid II in which R1 is lower alkyl, lower cycloalkyl or 2,4-difluorophenyl is described, in which boron 1-subst.- 6-fluoro-4-oxo-7-(4-subst.-1-piperazinyl)-1,4- dihydroquinoline-3-carboxylat...

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Hauptverfasser: SKET BORIS DR, BARBO MARTIN, ZUPET PAVEL DR, ZUPANCIC NATASA DR
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Sprache:eng ; ger
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator SKET BORIS DR
BARBO MARTIN
ZUPET PAVEL DR
ZUPANCIC NATASA DR
description A process for the preparation of 1-subst.-6-fluoro-4-oxo- 7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid II in which R1 is lower alkyl, lower cycloalkyl or 2,4-difluorophenyl is described, in which boron 1-subst.- 6-fluoro-4-oxo-7-(4-subst.-1-piperazinyl)-1,4- dihydroquinoline-3-carboxylate diacetate of the formula I is subjected to an alkaline hydrolysis. Compounds of the formula II are used in medicine for treating inflammatory disorders. The compound of the formula I is novel. It is obtained by nucleophilic substitution of the halogen atom in position 7 in boron 1-subst.-6-fluoro-4-oxo-7-halo-1,4- dihydroquinoline-3-carboxylate diacetate with 1-substituted piperazine.
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Compounds of the formula II are used in medicine for treating inflammatory disorders. The compound of the formula I is novel. It is obtained by nucleophilic substitution of the halogen atom in position 7 in boron 1-subst.-6-fluoro-4-oxo-7-halo-1,4- dihydroquinoline-3-carboxylate diacetate with 1-substituted piperazine.</description><edition>6</edition><language>eng ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19961025&amp;DB=EPODOC&amp;CC=AT&amp;NR=401648B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19961025&amp;DB=EPODOC&amp;CC=AT&amp;NR=401648B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SKET BORIS DR</creatorcontrib><creatorcontrib>BARBO MARTIN</creatorcontrib><creatorcontrib>ZUPET PAVEL DR</creatorcontrib><creatorcontrib>ZUPANCIC NATASA DR</creatorcontrib><title>PROCESS FOR THE PREPARATION OF 1-SUBST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, NOVEL INTERMEDIATE FOR USE IN THIS PROCESS AND PROCESS FOR THE PREPARATION OF THIS INTERMEDIATE</title><description>A process for the preparation of 1-subst.-6-fluoro-4-oxo- 7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid II in which R1 is lower alkyl, lower cycloalkyl or 2,4-difluorophenyl is described, in which boron 1-subst.- 6-fluoro-4-oxo-7-(4-subst.-1-piperazinyl)-1,4- dihydroquinoline-3-carboxylate diacetate of the formula I is subjected to an alkaline hydrolysis. Compounds of the formula II are used in medicine for treating inflammatory disorders. The compound of the formula I is novel. 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Compounds of the formula II are used in medicine for treating inflammatory disorders. The compound of the formula I is novel. It is obtained by nucleophilic substitution of the halogen atom in position 7 in boron 1-subst.-6-fluoro-4-oxo-7-halo-1,4- dihydroquinoline-3-carboxylate diacetate with 1-substituted piperazine.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PROCESS FOR THE PREPARATION OF 1-SUBST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, NOVEL INTERMEDIATE FOR USE IN THIS PROCESS AND PROCESS FOR THE PREPARATION OF THIS INTERMEDIATE
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