VERFAHREN ZUR HERSTELLUNG VON NEUEN CHINOLINDERIVATEN
The invention relates to new quinoline derivatives of the general Formula I (I) (wherein X stands for hydrogen, halogen or lower alkoxy; n is an integer of 1, 2 or 3; R1 represents hydrogen and R2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, (IV) w...
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| creator | LADANYI LASZLO DR VARGA LASZLO DR BERENYI EDIT DR HARTAI EVA PETOECZ LUJZA DR TOEMPE PETER DR KOVACS AGNES PALLOS LASZLO DR |
| description | The invention relates to new quinoline derivatives of the general Formula I (I) (wherein X stands for hydrogen, halogen or lower alkoxy; n is an integer of 1, 2 or 3; R1 represents hydrogen and R2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, (IV) wherein Z stands for -O-, -S-, -NH- or -N(lower alkyl)-; the dotted lines represent optional bonds; and m is 0 or 1; or R1 and R2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered heterocyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted), and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy. |
| format | Patent |
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The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy.</description><language>ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910410&DB=EPODOC&CC=AT&NR=392469B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910410&DB=EPODOC&CC=AT&NR=392469B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LADANYI LASZLO DR</creatorcontrib><creatorcontrib>VARGA LASZLO DR</creatorcontrib><creatorcontrib>BERENYI EDIT DR</creatorcontrib><creatorcontrib>HARTAI EVA</creatorcontrib><creatorcontrib>PETOECZ LUJZA DR</creatorcontrib><creatorcontrib>TOEMPE PETER DR</creatorcontrib><creatorcontrib>KOVACS AGNES</creatorcontrib><creatorcontrib>PALLOS LASZLO DR</creatorcontrib><title>VERFAHREN ZUR HERSTELLUNG VON NEUEN CHINOLINDERIVATEN</title><description>The invention relates to new quinoline derivatives of the general Formula I (I) (wherein X stands for hydrogen, halogen or lower alkoxy; n is an integer of 1, 2 or 3; R1 represents hydrogen and R2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, (IV) wherein Z stands for -O-, -S-, -NH- or -N(lower alkyl)-; the dotted lines represent optional bonds; and m is 0 or 1; or R1 and R2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered heterocyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted), and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDANcw1yc_QIcvVTiAoNUvBwDQoOcfXxCfVzVwjz91Pwcw0Fyjh7ePr5-3j6ubgGeYY5hrj68TCwpiXmFKfyQmluBnk31xBnD93Ugvz41OKCxOTUvNSSeMcQY0sjEzNLJydjwioAiIwnew</recordid><startdate>19910410</startdate><enddate>19910410</enddate><creator>LADANYI LASZLO DR</creator><creator>VARGA LASZLO DR</creator><creator>BERENYI EDIT DR</creator><creator>HARTAI EVA</creator><creator>PETOECZ LUJZA DR</creator><creator>TOEMPE PETER DR</creator><creator>KOVACS AGNES</creator><creator>PALLOS LASZLO DR</creator><scope>EVB</scope></search><sort><creationdate>19910410</creationdate><title>VERFAHREN ZUR HERSTELLUNG VON NEUEN CHINOLINDERIVATEN</title><author>LADANYI LASZLO DR ; VARGA LASZLO DR ; BERENYI EDIT DR ; HARTAI EVA ; PETOECZ LUJZA DR ; TOEMPE PETER DR ; KOVACS AGNES ; PALLOS LASZLO DR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AT392469BB3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>1991</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LADANYI LASZLO DR</creatorcontrib><creatorcontrib>VARGA LASZLO DR</creatorcontrib><creatorcontrib>BERENYI EDIT DR</creatorcontrib><creatorcontrib>HARTAI EVA</creatorcontrib><creatorcontrib>PETOECZ LUJZA DR</creatorcontrib><creatorcontrib>TOEMPE PETER DR</creatorcontrib><creatorcontrib>KOVACS AGNES</creatorcontrib><creatorcontrib>PALLOS LASZLO DR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LADANYI LASZLO DR</au><au>VARGA LASZLO DR</au><au>BERENYI EDIT DR</au><au>HARTAI EVA</au><au>PETOECZ LUJZA DR</au><au>TOEMPE PETER DR</au><au>KOVACS AGNES</au><au>PALLOS LASZLO DR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VERFAHREN ZUR HERSTELLUNG VON NEUEN CHINOLINDERIVATEN</title><date>1991-04-10</date><risdate>1991</risdate><abstract>The invention relates to new quinoline derivatives of the general Formula I (I) (wherein X stands for hydrogen, halogen or lower alkoxy; n is an integer of 1, 2 or 3; R1 represents hydrogen and R2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, (IV) wherein Z stands for -O-, -S-, -NH- or -N(lower alkyl)-; the dotted lines represent optional bonds; and m is 0 or 1; or R1 and R2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered heterocyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted), and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | VERFAHREN ZUR HERSTELLUNG VON NEUEN CHINOLINDERIVATEN |
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