VERFAHREN ZUR HERSTELLUNG DES NEUEN 17, 18 DEHYDROAPOVINCAMINOLS UND SEINER SAEUREADDITIONSSALZE

VERFAHREN ZUR HERSTELLUNG DES NEUEN 17, 18 DEHYDROAPOVINCAMINOLS UND SEINER SAEUREADDITIONSSALZE

The invention relates to a process for the preparation of the novel 17,18-dehydroapovincaminol of the formula I and its acid addition salts, which is characterized in that a compound of the formula II is reduced with a selective reducing agent, preferably a complex metal hydride, and, if desired, an...

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Hauptverfasser: KIRALY GYOENGYVER DR, FEKETE GYOERGY DR, ZAJER MARIA, ROSDY BELA DR, KEVE TIBOR DR, KIRALY ARPAD DR, LOERINCZ CSABA, FORGACH LILLA DR, SZPORNY LASZLO DR, KARPATI EGON DR, GALAMBOS JANOS, SZADON BELA DR
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The invention relates to a process for the preparation of the novel 17,18-dehydroapovincaminol of the formula I and its acid addition salts, which is characterized in that a compound of the formula II is reduced with a selective reducing agent, preferably a complex metal hydride, and, if desired, an acid addition salt is formed from the resulting compound of the formula I. The novel compound is an important intermediate for the preparation of 17,18-dehydroapovincaminol 3',4',5'- trimethoxybenzoate, which is active against cutaneous disorders, and of its acid addition salts.