Verfahren zur Herstellung von neuen basisch substituierten 2,3,7,8-Tetrahydro-1H-chino[1,8-ab][1]benzazepinen und von ihren Salzen

1321390 3-amino-2,3,7,8-tetrahydro-IH- quino[1,8-ab][1]benzazepines CHEMISCHE FABRIK PROMONTA GmbH 19 April 1971 [3 Feb 1970] 20983/71 Heading C2C Novel 3-amino-2,3,7,8-tetrahydro-IH-quino- [1,8-ab][1]benzazepines of the general formula wherein each of R 1 and R 2 is a hydrogen atom or a C 1 -C 4 alkyl group, and pharmaceutically acceptable acid addition salts thereof are prepared (a) by condensation of 3-oxo-2,3,7,8- tetrahydro - IH - quino[1,8 - ab][1]benzazepine with ammonia or an amine of the general formula R 1 R 2 NH under hydrogenation conditions; (b) when R 1 is a hydrogen atom, by condensation of the reactants used in (a) with elimination of water, followed by reduction; (c) when R 1 and R 2 are hydrogen atoms, by reaction of the ketone starting material used in (a) with hydroxylamine hydrochloride, followed by reduction of the resulting oxime; (d) by reaction of a 3-halo-2,3,7,8-tetrahydro-IH-quino[1,8-ab] [1]benzazepine with ammonia or an amine of the second general formula above; and (e) when R 1 and/or R 2 is/are alkyl group(s), by alkylation of the corresponding compound in which R 1 and/or R 2 is/are hydrogen atom(s); followed optionally by salification of the product. Pharmaceutical compositions comprise, as active ingredient, a 3-amino-2,3,7,8-tetrahydro- IH-quino[1,8-ab][1]benzezepine of the first general formula above or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutically acceptable carrier.