INHIBIDORES DE KRAS G12C Y MÉTODOS PARA SU USO

En la presente, se proveen inhibidores de KRAS G12C, que son útiles para el tratamiento de múltiples trastornos, los que incluyen cáncer pancreático, colorrectal y pulmonar. Reivindicación 1: Un compuesto, caracterizado porque el compuesto está seleccionado a partir de: los compuestos del grupo de f...

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Hauptverfasser: CEE, VICTOR J, CHEN, JIAN JEFFREY, LOPEZ, PATRICIA, NISHIMURA, NOBUKO, TAMAYO, NURIA A, KOPECKY, DAVID JOHN, NGUYEN, THOMAS T, ALLEN, JOHN GORDON, ALLEN, JENNIFER REBECCA, SHIN, YOUNGSOOK, LANMAN, BRIAN ALAN, REED, ANTHONY B, WURZ, RYAN, BOOKER, SHON, LIU, LONGBIN
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creator CEE, VICTOR J
CHEN, JIAN JEFFREY
LOPEZ, PATRICIA
NISHIMURA, NOBUKO
TAMAYO, NURIA A
KOPECKY, DAVID JOHN
NGUYEN, THOMAS T
ALLEN, JOHN GORDON
ALLEN, JENNIFER REBECCA
SHIN, YOUNGSOOK
LANMAN, BRIAN ALAN
REED, ANTHONY B
WURZ, RYAN
BOOKER, SHON
LIU, LONGBIN
description En la presente, se proveen inhibidores de KRAS G12C, que son útiles para el tratamiento de múltiples trastornos, los que incluyen cáncer pancreático, colorrectal y pulmonar. Reivindicación 1: Un compuesto, caracterizado porque el compuesto está seleccionado a partir de: los compuestos del grupo de fórmula (1); o una sal farmacéuticamente aceptable de este. Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title INHIBIDORES DE KRAS G12C Y MÉTODOS PARA SU USO
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