Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance

Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodi-lating activity with a reduced effect of tolerance, of the general formula (I) in which A and B independently represent any of the groups-ON02 and -Z-CO-R, wherein Z is an oxygen atom or sulphur...

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Hauptverfasser:	CABEZA LLORENTE Lydia, CARBO BANUS Marcel. li, NEGRIE ROFES Cristina, RADOMSKI Marek, CERDA RIUDAVETS Juan Antonio, SALAS PEREZ-RASILLA Eduardo, REPOLLES MOLINER Jose, PUBILL COY Francisco, BONNIN Juan Martinez, FERRER SISO Alicia
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	CABEZA LLORENTE Lydia CARBO BANUS Marcel. li NEGRIE ROFES Cristina RADOMSKI Marek CERDA RIUDAVETS Juan Antonio SALAS PEREZ-RASILLA Eduardo REPOLLES MOLINER Jose PUBILL COY Francisco BONNIN Juan Martinez FERRER SISO Alicia
description	Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodi-lating activity with a reduced effect of tolerance, of the general formula (I) in which A and B independently represent any of the groups-ON02 and -Z-CO-R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C1-C4 group, an aryl group or an aralkyl group eventually substituted, or the group in which R1 is hydrogen, or an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always -ON02, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance
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