Development of Type 1 Diabetes Mellitus in Nonobese Diabetic Mice Follows Changes in Thymocyte and Peripheral T Lymphocyte Transcriptional Activity

As early as one month of age, nonobese diabetic (NOD) mice feature pancreatic infiltration of autoreactive T lymphocytes, which destruct insulin-producing beta cells, producing autoimmune diabetes mellitus (T1D) within eight months. Thus, we hypothesized that during the development of T1D, the trans...

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Veröffentlicht in:	Journal of immunology research 2010, Vol.2011 (2011), p.1-12
Hauptverfasser:	Donadi, Eduardo Antônio, Sakamoto-Hojo, Elza Tiemi, Macedo, Claudia, Donate, Paula B., Fornari, Thais A., Passos, Geraldo A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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