Developmental Profiles of Mucosal Immunity in Pre-school Children
This study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating...
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Veröffentlicht in: | Journal of immunology research 2010, Vol.2010 (2010), p.1-10 |
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creator | Gleeson, Maree Kyd, Jennelle M. Occhipinti, Stefano Otczyk, Diana C. Ewing, Patricia Cripps, Allan W. |
description | This study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating to the child and the family. A daily illness log was kept for each child. A multivariate longitudinal analysis of the relation between immunoglobulins in saliva and age, gender, childcare experience, pre-school exposure, number of siblings, environmental tobacco smoke (ETS), atopy and hospitalisation was conducted. There was a positive association of higher IgA levels with the winter season and with children being older than 4 years (P |
doi_str_mv | 10.1155/2010/196785 |
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Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating to the child and the family. A daily illness log was kept for each child. A multivariate longitudinal analysis of the relation between immunoglobulins in saliva and age, gender, childcare experience, pre-school exposure, number of siblings, environmental tobacco smoke (ETS), atopy and hospitalisation was conducted. There was a positive association of higher IgA levels with the winter season and with children being older than 4 years (P<.001), having attended childcare prior to commencing pre-school (P<.05), and having been exposed to ETS at home (P<.05). Lower IgA levels were associated with being atopic (P<.05). Higher IgG levels were associated with exposure to ETS (P<.001), while lower levels were associated to having atopy. Higher IgM levels were associated with previous childcare experience (P<.01) whilst having been hospitalised was associated with having low salivary IgM levels (P<.01). Lagged analyses demonstrated that immunological parameters were affected by the number of respiratory infections in the preceding 2 months.]]></description><identifier>ISSN: 2314-8861</identifier><identifier>EISSN: 2314-7156</identifier><identifier>DOI: 10.1155/2010/196785</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><ispartof>Journal of immunology research, 2010, Vol.2010 (2010), p.1-10</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27928,27929</link.rule.ids></links><search><creatorcontrib>Gleeson, Maree</creatorcontrib><creatorcontrib>Kyd, Jennelle M.</creatorcontrib><creatorcontrib>Occhipinti, Stefano</creatorcontrib><creatorcontrib>Otczyk, Diana C.</creatorcontrib><creatorcontrib>Ewing, Patricia</creatorcontrib><creatorcontrib>Cripps, Allan W.</creatorcontrib><title>Developmental Profiles of Mucosal Immunity in Pre-school Children</title><title>Journal of immunology research</title><description><![CDATA[This study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating to the child and the family. A daily illness log was kept for each child. A multivariate longitudinal analysis of the relation between immunoglobulins in saliva and age, gender, childcare experience, pre-school exposure, number of siblings, environmental tobacco smoke (ETS), atopy and hospitalisation was conducted. There was a positive association of higher IgA levels with the winter season and with children being older than 4 years (P<.001), having attended childcare prior to commencing pre-school (P<.05), and having been exposed to ETS at home (P<.05). Lower IgA levels were associated with being atopic (P<.05). Higher IgG levels were associated with exposure to ETS (P<.001), while lower levels were associated to having atopy. Higher IgM levels were associated with previous childcare experience (P<.01) whilst having been hospitalised was associated with having low salivary IgM levels (P<.01). Lagged analyses demonstrated that immunological parameters were affected by the number of respiratory infections in the preceding 2 months.]]></description><issn>2314-8861</issn><issn>2314-7156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFiUELgjAYQEcUJOWpc7A_YO2bTucxrKhD0KG7iH3iYjrZNPDf58F7p_d4j5AdsAOAEEfOgB0hjRMpFsTjIURBAiJezi5lDGviO_dhjAGHMOLgkdMZv6hN12DbF5o-ramURkdNRR9DadzU7k0ztKofqWqnj4Era2M0zWql3xbbLVlVhXboz9yQ_fXyym4BNoXFqsg7qyYb81SmPIXw3_8BDUA7RQ</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Gleeson, Maree</creator><creator>Kyd, Jennelle M.</creator><creator>Occhipinti, Stefano</creator><creator>Otczyk, Diana C.</creator><creator>Ewing, Patricia</creator><creator>Cripps, Allan W.</creator><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope></search><sort><creationdate>2010</creationdate><title>Developmental Profiles of Mucosal Immunity in Pre-school Children</title><author>Gleeson, Maree ; Kyd, Jennelle M. ; Occhipinti, Stefano ; Otczyk, Diana C. ; Ewing, Patricia ; Cripps, Allan W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-emarefa_primary_9892913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gleeson, Maree</creatorcontrib><creatorcontrib>Kyd, Jennelle M.</creatorcontrib><creatorcontrib>Occhipinti, Stefano</creatorcontrib><creatorcontrib>Otczyk, Diana C.</creatorcontrib><creatorcontrib>Ewing, Patricia</creatorcontrib><creatorcontrib>Cripps, Allan W.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><jtitle>Journal of immunology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gleeson, Maree</au><au>Kyd, Jennelle M.</au><au>Occhipinti, Stefano</au><au>Otczyk, Diana C.</au><au>Ewing, Patricia</au><au>Cripps, Allan W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental Profiles of Mucosal Immunity in Pre-school Children</atitle><jtitle>Journal of immunology research</jtitle><date>2010</date><risdate>2010</risdate><volume>2010</volume><issue>2010</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>2314-8861</issn><eissn>2314-7156</eissn><abstract><![CDATA[This study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating to the child and the family. A daily illness log was kept for each child. A multivariate longitudinal analysis of the relation between immunoglobulins in saliva and age, gender, childcare experience, pre-school exposure, number of siblings, environmental tobacco smoke (ETS), atopy and hospitalisation was conducted. There was a positive association of higher IgA levels with the winter season and with children being older than 4 years (P<.001), having attended childcare prior to commencing pre-school (P<.05), and having been exposed to ETS at home (P<.05). Lower IgA levels were associated with being atopic (P<.05). Higher IgG levels were associated with exposure to ETS (P<.001), while lower levels were associated to having atopy. Higher IgM levels were associated with previous childcare experience (P<.01) whilst having been hospitalised was associated with having low salivary IgM levels (P<.01). Lagged analyses demonstrated that immunological parameters were affected by the number of respiratory infections in the preceding 2 months.]]></abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><doi>10.1155/2010/196785</doi><tpages>10</tpages></addata></record> |
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title | Developmental Profiles of Mucosal Immunity in Pre-school Children |
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