High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis

High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis

To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients. Methods. 287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their r...

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Veröffentlicht in:BioMed research international 2010, Vol.2010 (2010), p.1-5
Hauptverfasser: Qian, Jiaqi, Yan, Yucheng, Cao, Liou, Wang, Qin, Mou, Shan, Zhang, Minfang, Cai, Hong, Ni, Zhaohui, Shi, Beili, Yu, Zanzhe
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container_issue 2010
container_start_page 1
container_title BioMed research international
container_volume 2010
creator Qian, Jiaqi
Yan, Yucheng
Cao, Liou
Wang, Qin
Mou, Shan
Zhang, Minfang
Cai, Hong
Ni, Zhaohui
Shi, Beili
Yu, Zanzhe
description To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients. Methods. 287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis. Results. The prevalence of LVH in this cohort was 21.25% (n=61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, P
doi_str_mv 10.1155/2010/373426
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Methods. 287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis. Results. The prevalence of LVH in this cohort was 21.25% (n=61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, P&lt;.01), and correlated with left ventricular mass index (LVMI) (r=0.314, P=.001). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (β=0.338, P=.002) for LVH in patients with LN. Conclusions. Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2010/373426</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><ispartof>BioMed research international, 2010, Vol.2010 (2010), p.1-5</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Qian, Jiaqi</creatorcontrib><creatorcontrib>Yan, Yucheng</creatorcontrib><creatorcontrib>Cao, Liou</creatorcontrib><creatorcontrib>Wang, Qin</creatorcontrib><creatorcontrib>Mou, Shan</creatorcontrib><creatorcontrib>Zhang, Minfang</creatorcontrib><creatorcontrib>Cai, Hong</creatorcontrib><creatorcontrib>Ni, Zhaohui</creatorcontrib><creatorcontrib>Shi, Beili</creatorcontrib><creatorcontrib>Yu, Zanzhe</creatorcontrib><title>High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis</title><title>BioMed research international</title><description>To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients. Methods. 287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis. Results. The prevalence of LVH in this cohort was 21.25% (n=61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, P&lt;.01), and correlated with left ventricular mass index (LVMI) (r=0.314, P=.001). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (β=0.338, P=.002) for LVH in patients with LN. Conclusions. 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Methods. 287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis. Results. The prevalence of LVH in this cohort was 21.25% (n=61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, P&lt;.01), and correlated with left ventricular mass index (LVMI) (r=0.314, P=.001). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (β=0.338, P=.002) for LVH in patients with LN. Conclusions. 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title High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis
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