Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis
Vitamin B12 deficiency is common in developing countries and should be suspected in patients with unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case...
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| Veröffentlicht in: | Sultan Qaboos University medical journal 2015-08, Vol.15 (3), p.420-423 |
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| creator | Davidson , Robin Al-Shafaee , Mohammed El-Shafie , Kawther Samir , Nafisa Lakhtakia , Ritu Al-Mamary , Muna Al-Waili , Ahmed |
| description | Vitamin B12 deficiency is common in developing countries and should be suspected in patients with
unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency
include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old
man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised
hyperpigmentation of the palmar and dorsal aspects of both hands of two months’ duration. Other symptoms
included numbness of the hands, anorexia, weight loss, dizziness, fatigability and a sore mouth and tongue. There
was no evidence of hypocortisolaemia and a literature search revealed a possible B12 deficiency. The patient had
low serum B12 levels and megaloblastic anaemia. An intrinsic factor antibody test was negative. A gastric biopsy
revealed chronic gastritis. After B12 supplementation, the patient’s symptoms resolved. Family physicians should
familiarise themselves with atypical presentations of B12 deficiency. Many symptoms of this deficiency are reversible
if detected and treated early. |
| doi_str_mv | 10.18295/squmj.2015.15.03.019 |
| format | Article |
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unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency
include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old
man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised
hyperpigmentation of the palmar and dorsal aspects of both hands of two months’ duration. Other symptoms
included numbness of the hands, anorexia, weight loss, dizziness, fatigability and a sore mouth and tongue. There
was no evidence of hypocortisolaemia and a literature search revealed a possible B12 deficiency. The patient had
low serum B12 levels and megaloblastic anaemia. An intrinsic factor antibody test was negative. A gastric biopsy
revealed chronic gastritis. After B12 supplementation, the patient’s symptoms resolved. Family physicians should
familiarise themselves with atypical presentations of B12 deficiency. Many symptoms of this deficiency are reversible
if detected and treated early.</description><identifier>ISSN: 2075-051X</identifier><identifier>EISSN: 2075-0528</identifier><identifier>DOI: 10.18295/squmj.2015.15.03.019</identifier><identifier>PMID: 26357561</identifier><language>eng</language><publisher>Muscat - Oman: Sultan Qaboos University</publisher><subject>Atrophic Gastritis ; Case Report ; CHRONIC DISEASES ; Diseases ; Etiology ; GASTRITIS ; Hyperpigmentation ; OMAN ; Online Case Report ; PIGMENTATION DISORDERS ; Skin ; VITAMIN B12 ; Vitamin B12 Deficiency ; VITAMIN DEFICIENCY ; إضطرابات الإنصباغ ; إلتهاب المعدة ; الأمراض ; الأمراض الجلدية ; الأمراض المزمنة ; التهاب المعدة ; الجلد ; علم الأمراض ; عمان ; عوز الفيتامينات ; فيتامين ب 12 ; مسببات الأمراض</subject><ispartof>Sultan Qaboos University medical journal, 2015-08, Vol.15 (3), p.420-423</ispartof><rights>Copyright 2015, Sultan Qaboos University Medical Journal, All Rights Reserved 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a4369-d50afc51227cb525d85225a9a6208a3f90fa72a7e2c4db930df8a51ed4a839853</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://static.almanhal.com/covers/titl/75751/cover-lg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554280/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554280/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26357561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davidson , Robin</creatorcontrib><creatorcontrib>Al-Shafaee , Mohammed</creatorcontrib><creatorcontrib>El-Shafie , Kawther</creatorcontrib><creatorcontrib>Samir , Nafisa</creatorcontrib><creatorcontrib>Lakhtakia , Ritu</creatorcontrib><creatorcontrib>Al-Mamary , Muna</creatorcontrib><creatorcontrib>Al-Waili , Ahmed</creatorcontrib><title>Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis</title><title>Sultan Qaboos University medical journal</title><addtitle>Sultan Qaboos Univ Med J</addtitle><description>Vitamin B12 deficiency is common in developing countries and should be suspected in patients with
unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency
include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old
man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised
hyperpigmentation of the palmar and dorsal aspects of both hands of two months’ duration. Other symptoms
included numbness of the hands, anorexia, weight loss, dizziness, fatigability and a sore mouth and tongue. There
was no evidence of hypocortisolaemia and a literature search revealed a possible B12 deficiency. The patient had
low serum B12 levels and megaloblastic anaemia. An intrinsic factor antibody test was negative. A gastric biopsy
revealed chronic gastritis. After B12 supplementation, the patient’s symptoms resolved. Family physicians should
familiarise themselves with atypical presentations of B12 deficiency. Many symptoms of this deficiency are reversible
if detected and treated early.</description><subject>Atrophic Gastritis</subject><subject>Case Report</subject><subject>CHRONIC DISEASES</subject><subject>Diseases</subject><subject>Etiology</subject><subject>GASTRITIS</subject><subject>Hyperpigmentation</subject><subject>OMAN</subject><subject>Online Case Report</subject><subject>PIGMENTATION DISORDERS</subject><subject>Skin</subject><subject>VITAMIN B12</subject><subject>Vitamin B12 Deficiency</subject><subject>VITAMIN DEFICIENCY</subject><subject>إضطرابات الإنصباغ</subject><subject>إلتهاب المعدة</subject><subject>الأمراض</subject><subject>الأمراض الجلدية</subject><subject>الأمراض المزمنة</subject><subject>التهاب المعدة</subject><subject>الجلد</subject><subject>علم الأمراض</subject><subject>عمان</subject><subject>عوز الفيتامينات</subject><subject>فيتامين ب 12</subject><subject>مسببات الأمراض</subject><issn>2075-051X</issn><issn>2075-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkttuEzEQhlcIRKvSRyjyJTcJPuysvTdIJUBbKRJIBcSdNfEhcdldb-0NUnh6TFJCa43k0fifz6e_qi4YnTPFW3ib77f93ZxTBvMSVMwpa59Vp5xKmFHg6vkxZz9OqvOc72gZQsmGwcvqhDcCJDTstPq9jAa7kJ0ltz_DQK53o0tjWPdumHAKcSCYCZIvyeVSCcOa3O76cYo9iZ58DxP2pek94-SD88EEN5gdWcR-7ILBvXyxSXEIhlxOKY6bklxhnlKYQn5VvfDYZXf-MJ9V3z59_Lq4ni0_X90sLpczrEXTzixQ9AYY59KsgINVwDlgiw2nCoVvqUfJUTpuartqBbVeITBna1SiVSDOqpsD10a802MKPaadjhj0vhDTWmOagumcXrVGOeobg7WvKbWtso3DltGV4OitKax3B9a4XfXOmvImCbsn0KcrQ9jodfyla4CaK1oAbx4AKd5vXZ50H7JxXYeDi9usmWQMhORSFikcpCbFnJPzx20Y1Xsb6L0N9F8b6BJU6GKD0vf68RmPXf8-vQguDgJX6s7jUdHQBkD9X8eux2Hz6H6yAJj4AzGBxjA</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Davidson , Robin</creator><creator>Al-Shafaee , Mohammed</creator><creator>El-Shafie , Kawther</creator><creator>Samir , Nafisa</creator><creator>Lakhtakia , Ritu</creator><creator>Al-Mamary , Muna</creator><creator>Al-Waili , Ahmed</creator><general>Sultan Qaboos University</general><general>Sultan Qaboos University, College of Medicine and Health Sciences</general><general>Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences</general><scope>~6Z</scope><scope>AACQA</scope><scope>ADJCN</scope><scope>AEION</scope><scope>AHFXO</scope><scope>AHHHR</scope><scope>AHQOB</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150801</creationdate><title>Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis</title><author>Davidson , Robin ; Al-Shafaee , Mohammed ; El-Shafie , Kawther ; Samir , Nafisa ; Lakhtakia , Ritu ; Al-Mamary , Muna ; Al-Waili , Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a4369-d50afc51227cb525d85225a9a6208a3f90fa72a7e2c4db930df8a51ed4a839853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Atrophic Gastritis</topic><topic>Case Report</topic><topic>CHRONIC DISEASES</topic><topic>Diseases</topic><topic>Etiology</topic><topic>GASTRITIS</topic><topic>Hyperpigmentation</topic><topic>OMAN</topic><topic>Online Case Report</topic><topic>PIGMENTATION DISORDERS</topic><topic>Skin</topic><topic>VITAMIN B12</topic><topic>Vitamin B12 Deficiency</topic><topic>VITAMIN DEFICIENCY</topic><topic>إضطرابات الإنصباغ</topic><topic>إلتهاب المعدة</topic><topic>الأمراض</topic><topic>الأمراض الجلدية</topic><topic>الأمراض المزمنة</topic><topic>التهاب المعدة</topic><topic>الجلد</topic><topic>علم الأمراض</topic><topic>عمان</topic><topic>عوز الفيتامينات</topic><topic>فيتامين ب 12</topic><topic>مسببات الأمراض</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davidson , Robin</creatorcontrib><creatorcontrib>Al-Shafaee , Mohammed</creatorcontrib><creatorcontrib>El-Shafie , Kawther</creatorcontrib><creatorcontrib>Samir , Nafisa</creatorcontrib><creatorcontrib>Lakhtakia , Ritu</creatorcontrib><creatorcontrib>Al-Mamary , Muna</creatorcontrib><creatorcontrib>Al-Waili , Ahmed</creatorcontrib><collection>Al Manhal All Journals Collection</collection><collection>بنك معلومات "معرفة" لدراسات العلوم العسكرية والأمنية - e-Marefa Military & Security Database</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>مجلس التعاون الخليجي وإيران - e-Marefa The GCC-Iranian Affairs</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>دراسات الشرق الأوسط - e-Marefa Middle Eastern Studies</collection><collection>الشؤون الدولية والعربية - e-Marefa International & Arab Affairs</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Sultan Qaboos University medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davidson , Robin</au><au>Al-Shafaee , Mohammed</au><au>El-Shafie , Kawther</au><au>Samir , Nafisa</au><au>Lakhtakia , Ritu</au><au>Al-Mamary , Muna</au><au>Al-Waili , Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis</atitle><jtitle>Sultan Qaboos University medical journal</jtitle><addtitle>Sultan Qaboos Univ Med J</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>15</volume><issue>3</issue><spage>420</spage><epage>423</epage><pages>420-423</pages><issn>2075-051X</issn><eissn>2075-0528</eissn><abstract>Vitamin B12 deficiency is common in developing countries and should be suspected in patients with
unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency
include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old
man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised
hyperpigmentation of the palmar and dorsal aspects of both hands of two months’ duration. Other symptoms
included numbness of the hands, anorexia, weight loss, dizziness, fatigability and a sore mouth and tongue. There
was no evidence of hypocortisolaemia and a literature search revealed a possible B12 deficiency. The patient had
low serum B12 levels and megaloblastic anaemia. An intrinsic factor antibody test was negative. A gastric biopsy
revealed chronic gastritis. After B12 supplementation, the patient’s symptoms resolved. Family physicians should
familiarise themselves with atypical presentations of B12 deficiency. Many symptoms of this deficiency are reversible
if detected and treated early.</abstract><cop>Muscat - Oman</cop><pub>Sultan Qaboos University</pub><pmid>26357561</pmid><doi>10.18295/squmj.2015.15.03.019</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Sultan Qaboos University medical journal, 2015-08, Vol.15 (3), p.420-423 |
| issn | 2075-051X 2075-0528 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; PubMed Central |
| subjects | Atrophic Gastritis Case Report CHRONIC DISEASES Diseases Etiology GASTRITIS Hyperpigmentation OMAN Online Case Report PIGMENTATION DISORDERS Skin VITAMIN B12 Vitamin B12 Deficiency VITAMIN DEFICIENCY إضطرابات الإنصباغ إلتهاب المعدة الأمراض الأمراض الجلدية الأمراض المزمنة التهاب المعدة الجلد علم الأمراض عمان عوز الفيتامينات فيتامين ب 12 مسببات الأمراض |
| title | Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis |
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