JAK3/STAT5/6 Pathway Alterations Are Associated with Immune Deviation in CD8+ T Cells in Renal Cell Carcinoma Patients

To investigate the molecular mechanisms underlying altered T cell response in renal cell carcinoma (RCC) patients, we compared autologous and allogeneic CD8+ T cell responses against RCC line from RCC patients and their HLA-matched donors, using mixed lymphocyte/tumor cell cultures (MLTCs). In addit...

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Veröffentlicht in:	Journal of biomedicine & biotechnology 2010, Vol.2010 (2010), p.1-13
Hauptverfasser:	Gigante, Margherita, Cavalcanti, Elisabetta, Mancini, Vito, Battaglia, Michele, Ditonno, Pasquale, Capobianco, Carmela, Cincione, Raffaele I., Selvaggi, Francesco P., Herr, Wolfgang, Storkus, Walter J., Gesualdo, Loreto, Ranieri, Elena
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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