Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes : In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer”
This paper describes synthesis, characterization (NMR, FT-IR, microanalysis, and X-ray crystallography), in vitro anticancer activity of ortho/para-xylyl linked bis-imidazolium salts (4-5) and respective dinuclear Ag(I) N-heterocyclic carbene (NHC) complexes (6-7). All the compounds were tested for...
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| Veröffentlicht in: | Journal of chemistry 2013, Vol.2013 (2013), p.1-11 |
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| container_title | Journal of chemistry |
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| creator | Nasri, Siti Fatimah Haque, Rosenani A. Iqbal, Muhammad Adnan al-Rawi, Sawsan S. Jafari, Seyedeh Fatemeh Ahamed, Mohamed B. Khadeer Abdul Majid, A. M. S. |
| description | This paper describes synthesis, characterization (NMR, FT-IR, microanalysis, and X-ray crystallography), in vitro anticancer activity of ortho/para-xylyl linked bis-imidazolium salts (4-5) and respective dinuclear Ag(I) N-heterocyclic carbene (NHC) complexes (6-7). All the compounds were tested for their cytotoxicity against human colorectal cancer (HCT 116) and breast cancer (MCF-7) cell lines. According to cell viability measurements using MTT assay, all the complexes (6-7) showed a dose-dependent cytotoxic activity against both the cell lines, whereas respective salts (4-5) proved to be inactive. The complexes (6-7) demonstrated significant activity with IC50 values range 5.6–20.3 μM for HCT 116 and 1.12–6.38 μM for MCF-7. 5-Fluorouracil was used as standard drug (IC50 = 5.9 μM) for HCT 116, whereas tamoxifen was used as standard drug for MCF-7 (IC50 = 14 μM) cell line. |
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The complexes (6-7) demonstrated significant activity with IC50 values range 5.6–20.3 μM for HCT 116 and 1.12–6.38 μM for MCF-7. 5-Fluorouracil was used as standard drug (IC50 = 5.9 μM) for HCT 116, whereas tamoxifen was used as standard drug for MCF-7 (IC50 = 14 μM) cell line.</description><identifier>ISSN: 2090-9063</identifier><identifier>EISSN: 2090-9071</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><ispartof>Journal of chemistry, 2013, Vol.2013 (2013), p.1-11</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Nasri, Siti Fatimah</creatorcontrib><creatorcontrib>Haque, Rosenani A.</creatorcontrib><creatorcontrib>Iqbal, Muhammad Adnan</creatorcontrib><creatorcontrib>al-Rawi, Sawsan S.</creatorcontrib><creatorcontrib>Jafari, Seyedeh Fatemeh</creatorcontrib><creatorcontrib>Ahamed, Mohamed B. 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| source | DOAJ Directory of Open Access Journals; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| title | Synthesis, Characterization, and Crystal Structures of Bis-Imidazolium Salts and Respective Dinuclear Ag(I) N-Heterocyclic Carbene Complexes : In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer” |
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