A Sub-Chronic Toxicity Study of Mercuric Chloride in the Rat
Heavy metal accumulates mostly in mammalian liver and kidney as these organs involved in the detoxification and excretion of foreign materials. Chronic exposure of heavy metals leads to intoxication of these organs. In the present study sub-chronic effect of mercury (as mercuric chloride at a dose o...
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| Veröffentlicht in: | Jordan journal of biological sciences 2012-01, Vol.5 (2), p.141-146 |
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| container_title | Jordan journal of biological sciences |
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| creator | Saleem , Tahia H Oriquat , Ghaleb A Naik , Rajashri R |
| description | Heavy metal accumulates mostly in mammalian liver and kidney as these organs involved in the detoxification and excretion of foreign materials. Chronic exposure of heavy metals leads to intoxication of these organs. In the present study sub-chronic effect of mercury (as mercuric chloride at a dose of 3.75 mg / kg body weight) on biochemical parameter was studied on the experimental animals. Results revealed that mercury increased the aspartate transpeptidase (AST), alanine transpeptidase (ALT), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities significantly than control group. This study also indicates that mercury increases the level of urea and creatinine ; and decreases the iron level. Bioaccumulation of mercury was higher in kidney as compared to other organs. |
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Chronic exposure of heavy metals leads to intoxication of these organs. In the present study sub-chronic effect of mercury (as mercuric chloride at a dose of 3.75 mg / kg body weight) on biochemical parameter was studied on the experimental animals. Results revealed that mercury increased the aspartate transpeptidase (AST), alanine transpeptidase (ALT), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities significantly than control group. This study also indicates that mercury increases the level of urea and creatinine ; and decreases the iron level. 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Chronic exposure of heavy metals leads to intoxication of these organs. In the present study sub-chronic effect of mercury (as mercuric chloride at a dose of 3.75 mg / kg body weight) on biochemical parameter was studied on the experimental animals. Results revealed that mercury increased the aspartate transpeptidase (AST), alanine transpeptidase (ALT), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities significantly than control group. This study also indicates that mercury increases the level of urea and creatinine ; and decreases the iron level. Bioaccumulation of mercury was higher in kidney as compared to other organs.</description><subject>BIOACCUMULATION</subject><subject>BIOCHEMISTRY</subject><subject>CHLORIDES</subject><subject>HEAVY METALS</subject><subject>LIVER</subject><subject>Mercuric chloride</subject><subject>MERCURY</subject><subject>TOXICITY</subject><subject>Toxicology</subject><subject>التراكم الحيوي</subject><subject>الزئبق</subject><subject>السمية</subject><subject>الفلزات الثقيلة</subject><subject>الكبد</subject><subject>الكلوريد</subject><subject>الكيمياء الحيوية</subject><subject>علم السموم</subject><subject>كلوريد الزئبق</subject><issn>1995-6673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpFjMtqwzAURLVooSHNJxT0A4JcyZIiyCaYviCl0HgfrqUrrODYRbah_vsaWtrZzMAZzg1bgXNaGGPVHdsMw2W7xIKSVq7Y_sBPUy3KJvdd8rzqv5JP48xP4xRm3kf-RtlPeUFl0_Y5BeKp42ND_APHe3YbsR1o89trVj09VuWLOL4_v5aHo8CikKIIYMj5GsCGWOiw1eCkDVJRUMFhhBhr4yMiSo-glSKCHWoksAYlBrVmDz9aumKmiOfPnJY1nxXAovrn2F6xa7D9O0i7M1p9A9AySxY</recordid><startdate>20120106</startdate><enddate>20120106</enddate><creator>Saleem , Tahia H</creator><creator>Oriquat , Ghaleb A</creator><creator>Naik , Rajashri R</creator><general>The Hashemite University : The Deanship of Scientific Research and Graduate Studies</general><general>The Hashemite University, Deanship of Academic Research and Graduate</general><scope>~6Z</scope><scope>ADJCN</scope><scope>AHFXO</scope></search><sort><creationdate>20120106</creationdate><title>A Sub-Chronic Toxicity Study of Mercuric Chloride in the Rat</title><author>Saleem , Tahia H ; Oriquat , Ghaleb A ; Naik , Rajashri R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a442-4d16e9cb117df45d051927d23ed3d9af1ffb6cfaaa2ca1533ee18a5ae176a2ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>BIOACCUMULATION</topic><topic>BIOCHEMISTRY</topic><topic>CHLORIDES</topic><topic>HEAVY METALS</topic><topic>LIVER</topic><topic>Mercuric chloride</topic><topic>MERCURY</topic><topic>TOXICITY</topic><topic>Toxicology</topic><topic>التراكم الحيوي</topic><topic>الزئبق</topic><topic>السمية</topic><topic>الفلزات الثقيلة</topic><topic>الكبد</topic><topic>الكلوريد</topic><topic>الكيمياء الحيوية</topic><topic>علم السموم</topic><topic>كلوريد الزئبق</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saleem , Tahia H</creatorcontrib><creatorcontrib>Oriquat , Ghaleb A</creatorcontrib><creatorcontrib>Naik , Rajashri R</creatorcontrib><collection>Al Manhal All Journals Collection</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><jtitle>Jordan journal of biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saleem , Tahia H</au><au>Oriquat , Ghaleb A</au><au>Naik , Rajashri R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Sub-Chronic Toxicity Study of Mercuric Chloride in the Rat</atitle><jtitle>Jordan journal of biological sciences</jtitle><date>2012-01-06</date><risdate>2012</risdate><volume>5</volume><issue>2</issue><spage>141</spage><epage>146</epage><pages>141-146</pages><issn>1995-6673</issn><abstract>Heavy metal accumulates mostly in mammalian liver and kidney as these organs involved in the detoxification and excretion of foreign materials. Chronic exposure of heavy metals leads to intoxication of these organs. In the present study sub-chronic effect of mercury (as mercuric chloride at a dose of 3.75 mg / kg body weight) on biochemical parameter was studied on the experimental animals. Results revealed that mercury increased the aspartate transpeptidase (AST), alanine transpeptidase (ALT), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities significantly than control group. This study also indicates that mercury increases the level of urea and creatinine ; and decreases the iron level. Bioaccumulation of mercury was higher in kidney as compared to other organs.</abstract><cop>Az Zarqa' - Jordan</cop><pub>The Hashemite University : The Deanship of Scientific Research and Graduate Studies</pub><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1995-6673 |
| ispartof | Jordan journal of biological sciences, 2012-01, Vol.5 (2), p.141-146 |
| issn | 1995-6673 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | BIOACCUMULATION BIOCHEMISTRY CHLORIDES HEAVY METALS LIVER Mercuric chloride MERCURY TOXICITY Toxicology التراكم الحيوي الزئبق السمية الفلزات الثقيلة الكبد الكلوريد الكيمياء الحيوية علم السموم كلوريد الزئبق |
| title | A Sub-Chronic Toxicity Study of Mercuric Chloride in the Rat |
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