Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction
Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients duri...
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| Veröffentlicht in: | Journal of Immunology Research 2020, Vol.2020 (2020), p.1-9 |
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| creator | Pastor-Salgado, Selene Pérez-Velázquez, Nataly Chávez-Rueda, Adriana Karina Blanco-Favela, Francisco Vazquez-Gonzalez, Wendy Guadalupe Contreras-Rodríguez, Alicia Moreno-Ruíz, Luis Antonio Zentella-Dehesa, Alejandro Maravillas-Montero, José Luis Cabrera-Quintero, Alberto Jose Madrid-Miller, Alejandra Chávez-Sánchez, Luis Mora-Ruíz, Mónica Daniela Garza-Reyes, Montserrat Guadalupe Ramírez-Arias, Erick |
| description | Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion. |
| doi_str_mv | 10.1155/2020/5692829 |
| format | Article |
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Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion.</description><identifier>ISSN: 2314-8861</identifier><identifier>EISSN: 2314-7156</identifier><identifier>DOI: 10.1155/2020/5692829</identifier><identifier>PMID: 32676508</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Angina pectoris ; Angioplasty ; Antibodies ; Cardiovascular disease ; CD14 antigen ; CD16 antigen ; Cell activation ; Comparative analysis ; Creatinine ; Cytokines ; Heart attack ; Heart attacks ; Immunology ; Inflammatory diseases ; Interleukin 17 ; Interleukin 6 ; Interleukins ; Leukocyte migration ; Monocytes ; Myocardial infarction ; Patients ; Plasma ; Recruitment ; TLR4 protein ; Toll-like receptors ; Tumor necrosis factor-TNF</subject><ispartof>Journal of Immunology Research, 2020, Vol.2020 (2020), p.1-9</ispartof><rights>Copyright © 2020 Montserrat Guadalupe Garza-Reyes et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Montserrat Guadalupe Garza-Reyes et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Montserrat Guadalupe Garza-Reyes et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c612t-c0e610f47cb7ae7611a6c0eceb703e388a99555cac1f15cb07f8560c0b2009453</citedby><cites>FETCH-LOGICAL-c612t-c0e610f47cb7ae7611a6c0eceb703e388a99555cac1f15cb07f8560c0b2009453</cites><orcidid>0000-0003-0971-8193 ; 0000-0002-9637-946X ; 0000-0001-5339-3504</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336211/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336211/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,873,881,2096,4010,27900,27901,27902,53766,53768</link.rule.ids></links><search><contributor>Assmann, Charles Elias</contributor><creatorcontrib>Pastor-Salgado, Selene</creatorcontrib><creatorcontrib>Pérez-Velázquez, Nataly</creatorcontrib><creatorcontrib>Chávez-Rueda, Adriana Karina</creatorcontrib><creatorcontrib>Blanco-Favela, Francisco</creatorcontrib><creatorcontrib>Vazquez-Gonzalez, Wendy Guadalupe</creatorcontrib><creatorcontrib>Contreras-Rodríguez, Alicia</creatorcontrib><creatorcontrib>Moreno-Ruíz, Luis Antonio</creatorcontrib><creatorcontrib>Zentella-Dehesa, Alejandro</creatorcontrib><creatorcontrib>Maravillas-Montero, José Luis</creatorcontrib><creatorcontrib>Cabrera-Quintero, Alberto Jose</creatorcontrib><creatorcontrib>Madrid-Miller, Alejandra</creatorcontrib><creatorcontrib>Chávez-Sánchez, Luis</creatorcontrib><creatorcontrib>Mora-Ruíz, Mónica Daniela</creatorcontrib><creatorcontrib>Garza-Reyes, Montserrat Guadalupe</creatorcontrib><creatorcontrib>Ramírez-Arias, Erick</creatorcontrib><title>Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction</title><title>Journal of Immunology Research</title><description>Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion.</description><subject>Angina pectoris</subject><subject>Angioplasty</subject><subject>Antibodies</subject><subject>Cardiovascular disease</subject><subject>CD14 antigen</subject><subject>CD16 antigen</subject><subject>Cell activation</subject><subject>Comparative analysis</subject><subject>Creatinine</subject><subject>Cytokines</subject><subject>Heart attack</subject><subject>Heart attacks</subject><subject>Immunology</subject><subject>Inflammatory diseases</subject><subject>Interleukin 17</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Leukocyte migration</subject><subject>Monocytes</subject><subject>Myocardial infarction</subject><subject>Patients</subject><subject>Plasma</subject><subject>Recruitment</subject><subject>TLR4 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Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14+CD16- and CD14++CD16+/CD14+CD16++ monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14++CD16− and CD14++CD16+/CD14+CD16++ monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32676508</pmid><doi>10.1155/2020/5692829</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0971-8193</orcidid><orcidid>https://orcid.org/0000-0002-9637-946X</orcidid><orcidid>https://orcid.org/0000-0001-5339-3504</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Immunology Research, 2020, Vol.2020 (2020), p.1-9 |
| issn | 2314-8861 2314-7156 |
| language | eng |
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| source | Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Angina pectoris Angioplasty Antibodies Cardiovascular disease CD14 antigen CD16 antigen Cell activation Comparative analysis Creatinine Cytokines Heart attack Heart attacks Immunology Inflammatory diseases Interleukin 17 Interleukin 6 Interleukins Leukocyte migration Monocytes Myocardial infarction Patients Plasma Recruitment TLR4 protein Toll-like receptors Tumor necrosis factor-TNF |
| title | Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A08%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Interleukin-17%20in%20the%20Activation%20of%20Monocyte%20Subsets%20in%20Patients%20with%20ST-Segment%20Elevation%20Myocardial%20Infarction&rft.jtitle=Journal%20of%20Immunology%20Research&rft.au=Pastor-Salgado,%20Selene&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2314-8861&rft.eissn=2314-7156&rft_id=info:doi/10.1155/2020/5692829&rft_dat=%3Cgale_doaj_%3EA637850803%3C/gale_doaj_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2420064080&rft_id=info:pmid/32676508&rft_galeid=A637850803&rft_doaj_id=oai_doaj_org_article_25fc383b936f4b0282d9efeede5a950f&rfr_iscdi=true |