Natural IgM antibodies inhibit microvesicle-driven coagulation and thrombosis

Thrombosis and its associated complications are a major cause of morbidity and mortality worldwide. Microvesicles (MVs), a class of extracellular vesicles, are increasingly recognized as mediators of coagulation and biomarkers of thrombotic risk. Thus, identifying factors targeting MV-driven coagula...

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Veröffentlicht in:	Blood 2021-03, Vol.137 (10), p.1406-1415
Hauptverfasser:	Obermayer, Georg, Afonyushkin, Taras, Göderle, Laura, Puhm, Florian, Schrottmaier, Waltraud, Taqi, Soreen, Schwameis, Michael, Ay, Cihan, Pabinger, Ingrid, Jilma, Bernd, Assinger, Alice, Mackman, Nigel, Binder, Christoph J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Coagulation Blood Platelets - cytology Blood Platelets - metabolism Cell-Derived Microparticles - metabolism Hematology Humans Immunoglobulin M - analysis Immunoglobulin M - metabolism Life Sciences & Biomedicine Mice Mice, Inbred C57BL Science & Technology Thrombosis - blood Thrombosis - metabolism
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