1,N2-Ethenoguanine, a Mutagenic DNA Adduct, Is a Primary Substrate of Escherichia coliMismatch-specific Uracil-DNA Glycosylase and Human Alkylpurine-DNA-N-Glycosylase

The promutagenic and genotoxic exocyclic DNA adduct 1,N2-ethenoguanine (1,N2-εG) is a major product formed in DNA exposed to lipid peroxidation-derived aldehydes in vitro. Here, we report that two structurally unrelated proteins, theEscherichia coli mismatch-specific uracil-DNA glycosylase (MUG) and...

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Veröffentlicht in:	The Journal of biological chemistry 2002-07, Vol.277 (30), p.26987-26993
Hauptverfasser:	Saparbaev, Murat, Langouët, Sophie, Privezentzev, Cyril V., Guengerich, F. Peter, Cai, Hongliang, Elder, Rhoderick H., Laval, Jacques
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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