Antibody Mediated Rejection of the Lung: An ISHLT Consensus Report
Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid organ transplant recipients, there are no standardized diagnostic criteria or an agreed definition. Hence a working group was created by the International Society...
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| Veröffentlicht in: | The Journal of heart and lung transplantation 2016 |
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| container_title | The Journal of heart and lung transplantation |
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| creator | Levine, Deborah J, MD Glanville, Allan R, MBBS, MD, FRACP Aboyoun, Christina, BA, MBA Belperio, John, MD Benden, Christian, MD FCCP Berry, Gerald J, MD Hachem, Ramsey, MD Hayes, Don, MD, MS Neil, Desley, BMedSc, MBBS, PhD, FRCPath Reinsmoen, Nancy L., PhD, D(ABHI) Snyder, Laurie D, MD Sweet, Stuart, MD, PhD Tyan, Dolly, PhD Verleden, Geert, MD PhD Westall, Glen, FRACP PhD Yusen, Roger D, MD, MPH Zamora, Martin, MD Zeevi, Adriana, PhD |
| description | Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid organ transplant recipients, there are no standardized diagnostic criteria or an agreed definition. Hence a working group was created by the International Society for Heart and Lung Transplantation (ISHLT) with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed towards donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d (C4d) within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or subclinical (normal allograft function).This consensus definition will have clinical, therapeutic and research implications. |
| doi_str_mv | 10.1016/j.healun.2016.01.1223 |
| format | Article |
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Unlike AMR in other solid organ transplant recipients, there are no standardized diagnostic criteria or an agreed definition. Hence a working group was created by the International Society for Heart and Lung Transplantation (ISHLT) with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed towards donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d (C4d) within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or subclinical (normal allograft function).This consensus definition will have clinical, therapeutic and research implications.</description><identifier>ISSN: 1053-2498</identifier><identifier>DOI: 10.1016/j.healun.2016.01.1223</identifier><language>eng</language><subject>Surgery</subject><ispartof>The Journal of heart and lung transplantation, 2016</ispartof><rights>International Society for the Heart and Lung Transplantation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Levine, Deborah J, MD</creatorcontrib><creatorcontrib>Glanville, Allan R, MBBS, MD, FRACP</creatorcontrib><creatorcontrib>Aboyoun, Christina, BA, MBA</creatorcontrib><creatorcontrib>Belperio, John, MD</creatorcontrib><creatorcontrib>Benden, Christian, MD FCCP</creatorcontrib><creatorcontrib>Berry, Gerald J, MD</creatorcontrib><creatorcontrib>Hachem, Ramsey, MD</creatorcontrib><creatorcontrib>Hayes, Don, MD, MS</creatorcontrib><creatorcontrib>Neil, Desley, BMedSc, MBBS, PhD, FRCPath</creatorcontrib><creatorcontrib>Reinsmoen, Nancy L., PhD, D(ABHI)</creatorcontrib><creatorcontrib>Snyder, Laurie D, MD</creatorcontrib><creatorcontrib>Sweet, Stuart, MD, PhD</creatorcontrib><creatorcontrib>Tyan, Dolly, PhD</creatorcontrib><creatorcontrib>Verleden, Geert, MD PhD</creatorcontrib><creatorcontrib>Westall, Glen, FRACP PhD</creatorcontrib><creatorcontrib>Yusen, Roger D, MD, MPH</creatorcontrib><creatorcontrib>Zamora, Martin, MD</creatorcontrib><creatorcontrib>Zeevi, Adriana, PhD</creatorcontrib><title>Antibody Mediated Rejection of the Lung: An ISHLT Consensus Report</title><title>The Journal of heart and lung transplantation</title><description>Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid organ transplant recipients, there are no standardized diagnostic criteria or an agreed definition. Hence a working group was created by the International Society for Heart and Lung Transplantation (ISHLT) with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed towards donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d (C4d) within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or subclinical (normal allograft function).This consensus definition will have clinical, therapeutic and research implications.</description><subject>Surgery</subject><issn>1053-2498</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqljsuqwjAURTNQ8HHvJwj5AeM56fU5EFQUhTq5Og-1PWpqOZEmFfx7K_gHjjYLFpslRA9BIeBokKsrJUXFStekABVqHTVEG2EY9fXfdNISHe9zANDRULfFcsHBnlz2lHvKbBIok_-UUxqsY-nOMlxJxhVfZnLBcnfYxke5cuyJfeVr8-7K8COa56Tw9PvZrphv1sfVtk81PCyVJi0s2zQpbvQkn7uq5NozaLw2YA7vtHcZjgD1eDyJvj54ASREUSk</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Levine, Deborah J, MD</creator><creator>Glanville, Allan R, MBBS, MD, FRACP</creator><creator>Aboyoun, Christina, BA, MBA</creator><creator>Belperio, John, MD</creator><creator>Benden, Christian, MD FCCP</creator><creator>Berry, Gerald J, MD</creator><creator>Hachem, Ramsey, MD</creator><creator>Hayes, Don, MD, MS</creator><creator>Neil, Desley, BMedSc, MBBS, PhD, FRCPath</creator><creator>Reinsmoen, Nancy L., PhD, D(ABHI)</creator><creator>Snyder, Laurie D, MD</creator><creator>Sweet, Stuart, MD, PhD</creator><creator>Tyan, Dolly, PhD</creator><creator>Verleden, Geert, MD PhD</creator><creator>Westall, Glen, FRACP PhD</creator><creator>Yusen, Roger D, MD, MPH</creator><creator>Zamora, Martin, MD</creator><creator>Zeevi, Adriana, PhD</creator><scope/></search><sort><creationdate>2016</creationdate><title>Antibody Mediated Rejection of the Lung: An ISHLT Consensus Report</title><author>Levine, Deborah J, MD ; Glanville, Allan R, MBBS, MD, FRACP ; Aboyoun, Christina, BA, MBA ; Belperio, John, MD ; Benden, Christian, MD FCCP ; Berry, Gerald J, MD ; Hachem, Ramsey, MD ; Hayes, Don, MD, MS ; Neil, Desley, BMedSc, MBBS, PhD, FRCPath ; Reinsmoen, Nancy L., PhD, D(ABHI) ; Snyder, Laurie D, MD ; Sweet, Stuart, MD, PhD ; Tyan, Dolly, PhD ; Verleden, Geert, MD PhD ; Westall, Glen, FRACP PhD ; Yusen, Roger D, MD, MPH ; Zamora, Martin, MD ; Zeevi, Adriana, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S10532498160127783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levine, Deborah J, MD</creatorcontrib><creatorcontrib>Glanville, Allan R, MBBS, MD, FRACP</creatorcontrib><creatorcontrib>Aboyoun, Christina, BA, MBA</creatorcontrib><creatorcontrib>Belperio, John, MD</creatorcontrib><creatorcontrib>Benden, Christian, MD FCCP</creatorcontrib><creatorcontrib>Berry, Gerald J, MD</creatorcontrib><creatorcontrib>Hachem, Ramsey, MD</creatorcontrib><creatorcontrib>Hayes, Don, MD, MS</creatorcontrib><creatorcontrib>Neil, Desley, BMedSc, MBBS, PhD, FRCPath</creatorcontrib><creatorcontrib>Reinsmoen, Nancy L., PhD, D(ABHI)</creatorcontrib><creatorcontrib>Snyder, Laurie D, MD</creatorcontrib><creatorcontrib>Sweet, Stuart, MD, PhD</creatorcontrib><creatorcontrib>Tyan, Dolly, PhD</creatorcontrib><creatorcontrib>Verleden, Geert, MD PhD</creatorcontrib><creatorcontrib>Westall, Glen, FRACP PhD</creatorcontrib><creatorcontrib>Yusen, Roger D, MD, MPH</creatorcontrib><creatorcontrib>Zamora, Martin, MD</creatorcontrib><creatorcontrib>Zeevi, Adriana, PhD</creatorcontrib><jtitle>The Journal of heart and lung transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levine, Deborah J, MD</au><au>Glanville, Allan R, MBBS, MD, FRACP</au><au>Aboyoun, Christina, BA, MBA</au><au>Belperio, John, MD</au><au>Benden, Christian, MD FCCP</au><au>Berry, Gerald J, MD</au><au>Hachem, Ramsey, MD</au><au>Hayes, Don, MD, MS</au><au>Neil, Desley, BMedSc, MBBS, PhD, FRCPath</au><au>Reinsmoen, Nancy L., PhD, D(ABHI)</au><au>Snyder, Laurie D, MD</au><au>Sweet, Stuart, MD, PhD</au><au>Tyan, Dolly, PhD</au><au>Verleden, Geert, MD PhD</au><au>Westall, Glen, FRACP PhD</au><au>Yusen, Roger D, MD, MPH</au><au>Zamora, Martin, MD</au><au>Zeevi, Adriana, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody Mediated Rejection of the Lung: An ISHLT Consensus Report</atitle><jtitle>The Journal of heart and lung transplantation</jtitle><date>2016</date><risdate>2016</risdate><issn>1053-2498</issn><abstract>Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid organ transplant recipients, there are no standardized diagnostic criteria or an agreed definition. Hence a working group was created by the International Society for Heart and Lung Transplantation (ISHLT) with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed towards donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d (C4d) within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or subclinical (normal allograft function).This consensus definition will have clinical, therapeutic and research implications.</abstract><doi>10.1016/j.healun.2016.01.1223</doi></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Surgery |
| title | Antibody Mediated Rejection of the Lung: An ISHLT Consensus Report |
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