Visual and quantitative EEG analysis in healthy term neonates within the first 6 hours and the third day of birth
Abstract Background “Normal” background EEG immediately after birth is unknown. We performed video-EEG recordings in the first 6 hours (first measure) and the third day of life (second measure) for evidence of transient changes of brain function. Main procedures. Design Cohort study of an incidental...
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| creator | Castro Conde, José R., MD, PhD Barrios, Desiré González, MD Campo, Candelaria González, MD González González, Nieves L., MD, PhD Millán, Beatriz Reyes, MD Sosa, Alejandro Jiménez, PhD |
| description | Abstract Background “Normal” background EEG immediately after birth is unknown. We performed video-EEG recordings in the first 6 hours (first measure) and the third day of life (second measure) for evidence of transient changes of brain function. Main procedures. Design Cohort study of an incidental sample of healthy full-term neonates in a single-centre nursery. Main outcome measures: 1) The EEG visual analysis included sleep-wake cycles, proportions of discontinuity and bursts with delta brushes, and number per hour of alpha/theta rolandic activity (A/TRA), encoches frontales and transients; and 2) The EEG spectral analysis included power spectrum in the following frequency bands: delta 0.5-4 Hz; theta 4-8 Hz; alpha 8-13 Hz and beta 13-30 Hz. Theta/delta (TDR) and alpha/delta (ADR) ratios were also calculated. Main findings Twenty-two babies were enrolled. Significant findings ( P |
| doi_str_mv | 10.1016/j.pediatrneurol.2017.04.024 |
| format | Article |
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We performed video-EEG recordings in the first 6 hours (first measure) and the third day of life (second measure) for evidence of transient changes of brain function. Main procedures. Design Cohort study of an incidental sample of healthy full-term neonates in a single-centre nursery. Main outcome measures: 1) The EEG visual analysis included sleep-wake cycles, proportions of discontinuity and bursts with delta brushes, and number per hour of alpha/theta rolandic activity (A/TRA), encoches frontales and transients; and 2) The EEG spectral analysis included power spectrum in the following frequency bands: delta 0.5-4 Hz; theta 4-8 Hz; alpha 8-13 Hz and beta 13-30 Hz. Theta/delta (TDR) and alpha/delta (ADR) ratios were also calculated. Main findings Twenty-two babies were enrolled. Significant findings ( P <0.05) in the first 6 hours with respect to 48-72 hours of life were: 1) increased discontinuity, indeterminate sleep, and bursts with delta brushes; 2) higher number of transients, and lower of A/TRA and encoches frontales. Minimal changes were found in power spectrum data. However, using ROC curve analysis, TDR≤0.484 was the best cut-off to discriminate between the two measures (positive predictive value: 100.0; 95% CI: 71.0-100). Principal conclusions in healthy term neonates, immature EEG patterns, lack of clearly defined sleep-wake cycles and frequent transients can be considered normal EEG findings in the first 6 hours of life. Normative power spectrum data are provided. These findings suggest that neonatal adaptation immediately after birth leads to transient changes of brain function.</description><identifier>ISSN: 0887-8994</identifier><identifier>DOI: 10.1016/j.pediatrneurol.2017.04.024</identifier><language>eng</language><subject>Neurology ; Pediatrics</subject><ispartof>Pediatric neurology, 2017</ispartof><rights>The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Castro Conde, José R., MD, PhD</creatorcontrib><creatorcontrib>Barrios, Desiré González, MD</creatorcontrib><creatorcontrib>Campo, Candelaria González, MD</creatorcontrib><creatorcontrib>González González, Nieves L., MD, PhD</creatorcontrib><creatorcontrib>Millán, Beatriz Reyes, MD</creatorcontrib><creatorcontrib>Sosa, Alejandro Jiménez, PhD</creatorcontrib><title>Visual and quantitative EEG analysis in healthy term neonates within the first 6 hours and the third day of birth</title><title>Pediatric neurology</title><description>Abstract Background “Normal” background EEG immediately after birth is unknown. We performed video-EEG recordings in the first 6 hours (first measure) and the third day of life (second measure) for evidence of transient changes of brain function. Main procedures. Design Cohort study of an incidental sample of healthy full-term neonates in a single-centre nursery. Main outcome measures: 1) The EEG visual analysis included sleep-wake cycles, proportions of discontinuity and bursts with delta brushes, and number per hour of alpha/theta rolandic activity (A/TRA), encoches frontales and transients; and 2) The EEG spectral analysis included power spectrum in the following frequency bands: delta 0.5-4 Hz; theta 4-8 Hz; alpha 8-13 Hz and beta 13-30 Hz. Theta/delta (TDR) and alpha/delta (ADR) ratios were also calculated. Main findings Twenty-two babies were enrolled. Significant findings ( P <0.05) in the first 6 hours with respect to 48-72 hours of life were: 1) increased discontinuity, indeterminate sleep, and bursts with delta brushes; 2) higher number of transients, and lower of A/TRA and encoches frontales. Minimal changes were found in power spectrum data. However, using ROC curve analysis, TDR≤0.484 was the best cut-off to discriminate between the two measures (positive predictive value: 100.0; 95% CI: 71.0-100). Principal conclusions in healthy term neonates, immature EEG patterns, lack of clearly defined sleep-wake cycles and frequent transients can be considered normal EEG findings in the first 6 hours of life. Normative power spectrum data are provided. These findings suggest that neonatal adaptation immediately after birth leads to transient changes of brain function.</description><subject>Neurology</subject><subject>Pediatrics</subject><issn>0887-8994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqlj81OwzAQhH0AqeXnHVbi3LBO0ya5cEEB7lRcI9Ns5A3GoV6nKG-Pg3gDTqOZkT7NKHWnMdOo9_dD9kUdmxg8TWF0WY66zLDIMC8u1BqrqtxUdV2s1JXIgIi7Oi_W6vTGMhkHxndwmoyPHE3kM0HTPKfQuFlYgD1YMi7aGSKFT_A0ehNJ4JujTWW0BD0HibAHO05BfnlLmurQQWdmGHt45xDtjbrsjRO6_dNr9fDUHB5fNpTMmSm0R8eej8Z90EwyJFyaIa1uJW-xfV2eLEd0ucU8yfbfgB-YXWZS</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Castro Conde, José R., MD, PhD</creator><creator>Barrios, Desiré González, MD</creator><creator>Campo, Candelaria González, MD</creator><creator>González González, Nieves L., MD, PhD</creator><creator>Millán, Beatriz Reyes, MD</creator><creator>Sosa, Alejandro Jiménez, PhD</creator><scope/></search><sort><creationdate>2017</creationdate><title>Visual and quantitative EEG analysis in healthy term neonates within the first 6 hours and the third day of birth</title><author>Castro Conde, José R., MD, PhD ; Barrios, Desiré González, MD ; Campo, Candelaria González, MD ; González González, Nieves L., MD, PhD ; Millán, Beatriz Reyes, MD ; Sosa, Alejandro Jiménez, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S08878994173029413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Neurology</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castro Conde, José R., MD, PhD</creatorcontrib><creatorcontrib>Barrios, Desiré González, MD</creatorcontrib><creatorcontrib>Campo, Candelaria González, MD</creatorcontrib><creatorcontrib>González González, Nieves L., MD, PhD</creatorcontrib><creatorcontrib>Millán, Beatriz Reyes, MD</creatorcontrib><creatorcontrib>Sosa, Alejandro Jiménez, PhD</creatorcontrib><jtitle>Pediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castro Conde, José R., MD, PhD</au><au>Barrios, Desiré González, MD</au><au>Campo, Candelaria González, MD</au><au>González González, Nieves L., MD, PhD</au><au>Millán, Beatriz Reyes, MD</au><au>Sosa, Alejandro Jiménez, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual and quantitative EEG analysis in healthy term neonates within the first 6 hours and the third day of birth</atitle><jtitle>Pediatric neurology</jtitle><date>2017</date><risdate>2017</risdate><issn>0887-8994</issn><abstract>Abstract Background “Normal” background EEG immediately after birth is unknown. We performed video-EEG recordings in the first 6 hours (first measure) and the third day of life (second measure) for evidence of transient changes of brain function. Main procedures. Design Cohort study of an incidental sample of healthy full-term neonates in a single-centre nursery. Main outcome measures: 1) The EEG visual analysis included sleep-wake cycles, proportions of discontinuity and bursts with delta brushes, and number per hour of alpha/theta rolandic activity (A/TRA), encoches frontales and transients; and 2) The EEG spectral analysis included power spectrum in the following frequency bands: delta 0.5-4 Hz; theta 4-8 Hz; alpha 8-13 Hz and beta 13-30 Hz. Theta/delta (TDR) and alpha/delta (ADR) ratios were also calculated. Main findings Twenty-two babies were enrolled. Significant findings ( P <0.05) in the first 6 hours with respect to 48-72 hours of life were: 1) increased discontinuity, indeterminate sleep, and bursts with delta brushes; 2) higher number of transients, and lower of A/TRA and encoches frontales. Minimal changes were found in power spectrum data. However, using ROC curve analysis, TDR≤0.484 was the best cut-off to discriminate between the two measures (positive predictive value: 100.0; 95% CI: 71.0-100). Principal conclusions in healthy term neonates, immature EEG patterns, lack of clearly defined sleep-wake cycles and frequent transients can be considered normal EEG findings in the first 6 hours of life. Normative power spectrum data are provided. These findings suggest that neonatal adaptation immediately after birth leads to transient changes of brain function.</abstract><doi>10.1016/j.pediatrneurol.2017.04.024</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Neurology Pediatrics |
| title | Visual and quantitative EEG analysis in healthy term neonates within the first 6 hours and the third day of birth |
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