ACEi-Induced Angioedema Worsened with FFP

ACEi-Induced Angioedema Worsened with FFP

Abstract Fresh frozen plasma (FFP) has been used as an intervention for hereditary angioedema and for angioedema induced by the use of angiotensin-converting enzyme inhibitors (ACEi). The mediator for both types of attacks is believed to be bradykinin. FFP would seem a reasonable treatment because i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The American journal of emergency medicine 2016
Hauptverfasser: Wilkerson, R. Gentry, MD, Adebayo, Omoyemi, MD
Format: Artikel
Sprache:eng
Schlagworte:
Emergency
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title The American journal of emergency medicine
container_volume
creator Wilkerson, R. Gentry, MD
Adebayo, Omoyemi, MD
description Abstract Fresh frozen plasma (FFP) has been used as an intervention for hereditary angioedema and for angioedema induced by the use of angiotensin-converting enzyme inhibitors (ACEi). The mediator for both types of attacks is believed to be bradykinin. FFP would seem a reasonable treatment because it contains enzymes that break down bradykinin; however, it also contains high-molecular-weight kininogen and kallikrein, the substrates required to form it. To balance case reports describing the resolution of ACEi-induced angioedema after administration of FFP, we describe the worsening of angioedema after its administration to a 68-year-old man who had been taking lisinopril for a year.
doi_str_mv 10.1016/j.ajem.2016.06.089
format Article
fullrecord <record><control><sourceid>elsevier</sourceid><recordid>TN_cdi_elsevier_clinicalkeyesjournals_1_s2_0_S0735675716303394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0735675716303394</els_id><sourcerecordid>1_s2_0_S0735675716303394</sourcerecordid><originalsourceid>FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S07356757163033943</originalsourceid><addsrcrecordid>eNqlTksKwjAUzELB-rmAq25dNL40_diNUEqL7gQFlyG0T01tU2is4u2N4A2EgfkwDEPIkgFlwKJ1TWWNLfWtpmCxSUbEgZiHXhSH8YRMjakBGAvCwCGrNMuVt9fVUGLlpvqqOqywle656w1qm73U4-YWxWFOxhfZGFz8eEa2RX7Kdh5a81TYi7JRWpWyueMbTd0NvbY9wYTxBYjj98H3AIs4cJ4E_O-BD-ZKRxQ</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>ACEi-Induced Angioedema Worsened with FFP</title><source>Elsevier ScienceDirect Journals Complete</source><source>ProQuest Central</source><creator>Wilkerson, R. Gentry, MD ; Adebayo, Omoyemi, MD</creator><creatorcontrib>Wilkerson, R. Gentry, MD ; Adebayo, Omoyemi, MD</creatorcontrib><description>Abstract Fresh frozen plasma (FFP) has been used as an intervention for hereditary angioedema and for angioedema induced by the use of angiotensin-converting enzyme inhibitors (ACEi). The mediator for both types of attacks is believed to be bradykinin. FFP would seem a reasonable treatment because it contains enzymes that break down bradykinin; however, it also contains high-molecular-weight kininogen and kallikrein, the substrates required to form it. To balance case reports describing the resolution of ACEi-induced angioedema after administration of FFP, we describe the worsening of angioedema after its administration to a 68-year-old man who had been taking lisinopril for a year.</description><identifier>ISSN: 0735-6757</identifier><identifier>DOI: 10.1016/j.ajem.2016.06.089</identifier><language>eng</language><subject>Emergency</subject><ispartof>The American journal of emergency medicine, 2016</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Wilkerson, R. Gentry, MD</creatorcontrib><creatorcontrib>Adebayo, Omoyemi, MD</creatorcontrib><title>ACEi-Induced Angioedema Worsened with FFP</title><title>The American journal of emergency medicine</title><description>Abstract Fresh frozen plasma (FFP) has been used as an intervention for hereditary angioedema and for angioedema induced by the use of angiotensin-converting enzyme inhibitors (ACEi). The mediator for both types of attacks is believed to be bradykinin. FFP would seem a reasonable treatment because it contains enzymes that break down bradykinin; however, it also contains high-molecular-weight kininogen and kallikrein, the substrates required to form it. To balance case reports describing the resolution of ACEi-induced angioedema after administration of FFP, we describe the worsening of angioedema after its administration to a 68-year-old man who had been taking lisinopril for a year.</description><subject>Emergency</subject><issn>0735-6757</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqlTksKwjAUzELB-rmAq25dNL40_diNUEqL7gQFlyG0T01tU2is4u2N4A2EgfkwDEPIkgFlwKJ1TWWNLfWtpmCxSUbEgZiHXhSH8YRMjakBGAvCwCGrNMuVt9fVUGLlpvqqOqywle656w1qm73U4-YWxWFOxhfZGFz8eEa2RX7Kdh5a81TYi7JRWpWyueMbTd0NvbY9wYTxBYjj98H3AIs4cJ4E_O-BD-ZKRxQ</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Wilkerson, R. Gentry, MD</creator><creator>Adebayo, Omoyemi, MD</creator><scope/></search><sort><creationdate>2016</creationdate><title>ACEi-Induced Angioedema Worsened with FFP</title><author>Wilkerson, R. Gentry, MD ; Adebayo, Omoyemi, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S07356757163033943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Emergency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilkerson, R. Gentry, MD</creatorcontrib><creatorcontrib>Adebayo, Omoyemi, MD</creatorcontrib><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilkerson, R. Gentry, MD</au><au>Adebayo, Omoyemi, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ACEi-Induced Angioedema Worsened with FFP</atitle><jtitle>The American journal of emergency medicine</jtitle><date>2016</date><risdate>2016</risdate><issn>0735-6757</issn><abstract>Abstract Fresh frozen plasma (FFP) has been used as an intervention for hereditary angioedema and for angioedema induced by the use of angiotensin-converting enzyme inhibitors (ACEi). The mediator for both types of attacks is believed to be bradykinin. FFP would seem a reasonable treatment because it contains enzymes that break down bradykinin; however, it also contains high-molecular-weight kininogen and kallikrein, the substrates required to form it. To balance case reports describing the resolution of ACEi-induced angioedema after administration of FFP, we describe the worsening of angioedema after its administration to a 68-year-old man who had been taking lisinopril for a year.</abstract><doi>10.1016/j.ajem.2016.06.089</doi></addata></record>
fulltext fulltext
identifier ISSN: 0735-6757
ispartof The American journal of emergency medicine, 2016
issn 0735-6757
language eng
recordid cdi_elsevier_clinicalkeyesjournals_1_s2_0_S0735675716303394
source Elsevier ScienceDirect Journals Complete; ProQuest Central
subjects Emergency
title ACEi-Induced Angioedema Worsened with FFP
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T10%3A42%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=ACEi-Induced%20Angioedema%20Worsened%20with%20FFP&rft.jtitle=The%20American%20journal%20of%20emergency%20medicine&rft.au=Wilkerson,%20R.%20Gentry,%20MD&rft.date=2016&rft.issn=0735-6757&rft_id=info:doi/10.1016/j.ajem.2016.06.089&rft_dat=%3Celsevier%3E1_s2_0_S0735675716303394%3C/elsevier%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_els_id=1_s2_0_S0735675716303394&rfr_iscdi=true