1 H magnetic resonance spectroscopy of the normal testis: preliminary findings
Abstract Purpose The purpose of this study was to determine the pre- and postpubertal1 H magnetic resonance spectroscopic characteristics of the normal testis to establish baseline values for further clinical studies. Materials and Methods The subjects consisted of male volunteers, of whom 19 were p...
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| Veröffentlicht in: | Magnetic resonance imaging 2008, Vol.26 (2), p.215-220 |
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| creator | Firat, Ahmet Kemal Uğraş, Murat Karakaş, Hakkı M Erdem, Gülnur Kurus, Meltem Ugras, Meltem Celik, Tayfun Kahraman, Bayram Doğanay, Selim |
| description | Abstract Purpose The purpose of this study was to determine the pre- and postpubertal1 H magnetic resonance spectroscopic characteristics of the normal testis to establish baseline values for further clinical studies. Materials and Methods The subjects consisted of male volunteers, of whom 19 were prepubertal with ages between 7 and 13 years and 24 were postpubertal with ages between 19 and 39 years. Their testes were evaluated at 1.5 T with magnetic resonance spectroscopy; in addition, testis volumes were measured. Major metabolite peaks were identified and their ratios were calculated. Metabolite differences of testis between pre- and postpubertal age were analyzed. Results Major constituents of spectra were 3.21 ppm choline and 0.9–1.3 ppm lipid peaks. At the echo time (TE) spectrum of 31 ms, choline/lipid ratios ranged from 0.35 to 8.30 (mean=1.87) in postpubertal males and from 0.06 to 5.45 (mean=0.88) in prepubertal males ( P |
| doi_str_mv | 10.1016/j.mri.2007.06.008 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier</sourceid><recordid>TN_cdi_elsevier_clinicalkeyesjournals_1_s2_0_S0730725X07003463</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0730725X07003463</els_id><sourcerecordid>1_s2_0_S0730725X07003463</sourcerecordid><originalsourceid>FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S0730725X070034633</originalsourceid><addsrcrecordid>eNqljj1OAzEQRl0EifBzALq5QMx4ze5GKdIgUCoaKOgsy8yGWbz2ymOQ9vYkEjegevqkp09PqTuD2qDp7kc9FdYNYq-x04jblVpjb3HTN-37pboSGRGxbWy7Vi8GDjD5Y6LKAQpJTj4FApkp1JIl5HmBPED9JEi5TD5CJaksO5gLRZ44-bLAwOmD01Fu1MXgo9DtH6_V_vnp7fGwodP4YSouRE4cfPyihWTM3yWdPGecNA7d6znzXIk9on3orP33wS8gZlYS</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>1 H magnetic resonance spectroscopy of the normal testis: preliminary findings</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Firat, Ahmet Kemal ; Uğraş, Murat ; Karakaş, Hakkı M ; Erdem, Gülnur ; Kurus, Meltem ; Ugras, Meltem ; Celik, Tayfun ; Kahraman, Bayram ; Doğanay, Selim</creator><creatorcontrib>Firat, Ahmet Kemal ; Uğraş, Murat ; Karakaş, Hakkı M ; Erdem, Gülnur ; Kurus, Meltem ; Ugras, Meltem ; Celik, Tayfun ; Kahraman, Bayram ; Doğanay, Selim</creatorcontrib><description>Abstract Purpose The purpose of this study was to determine the pre- and postpubertal1 H magnetic resonance spectroscopic characteristics of the normal testis to establish baseline values for further clinical studies. Materials and Methods The subjects consisted of male volunteers, of whom 19 were prepubertal with ages between 7 and 13 years and 24 were postpubertal with ages between 19 and 39 years. Their testes were evaluated at 1.5 T with magnetic resonance spectroscopy; in addition, testis volumes were measured. Major metabolite peaks were identified and their ratios were calculated. Metabolite differences of testis between pre- and postpubertal age were analyzed. Results Major constituents of spectra were 3.21 ppm choline and 0.9–1.3 ppm lipid peaks. At the echo time (TE) spectrum of 31 ms, choline/lipid ratios ranged from 0.35 to 8.30 (mean=1.87) in postpubertal males and from 0.06 to 5.45 (mean=0.88) in prepubertal males ( P <.013). At the TE spectrum of 136 ms, choline/lipid ratios ranged from 0.66 to 15.42 (mean=4.09) in postpubertal males and from 0.05 to 4.91 (mean=0.9) in prepubertal males ( P <.016). Conclusions Choline/lipid ratio was higher in the postpubertal period. The existence of higher choline peak in that age group should be due to the initiation of spermatogenesis. The decrease in the lipid peak may represent the effect of testosterone on testicular tissue or may be due to histochemical changes initiated by puberty. The significant decrease in choline/lipid ratio noted after puberty could represent the presence of spermatogenesis. This hypothesis should be evaluated by further studies on postpubertal subjects with impaired spermatogenesis.</description><identifier>ISSN: 0730-725X</identifier><identifier>DOI: 10.1016/j.mri.2007.06.008</identifier><language>eng</language><subject>Radiology</subject><ispartof>Magnetic resonance imaging, 2008, Vol.26 (2), p.215-220</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27921,27922,27923</link.rule.ids></links><search><creatorcontrib>Firat, Ahmet Kemal</creatorcontrib><creatorcontrib>Uğraş, Murat</creatorcontrib><creatorcontrib>Karakaş, Hakkı M</creatorcontrib><creatorcontrib>Erdem, Gülnur</creatorcontrib><creatorcontrib>Kurus, Meltem</creatorcontrib><creatorcontrib>Ugras, Meltem</creatorcontrib><creatorcontrib>Celik, Tayfun</creatorcontrib><creatorcontrib>Kahraman, Bayram</creatorcontrib><creatorcontrib>Doğanay, Selim</creatorcontrib><title>1 H magnetic resonance spectroscopy of the normal testis: preliminary findings</title><title>Magnetic resonance imaging</title><description>Abstract Purpose The purpose of this study was to determine the pre- and postpubertal1 H magnetic resonance spectroscopic characteristics of the normal testis to establish baseline values for further clinical studies. Materials and Methods The subjects consisted of male volunteers, of whom 19 were prepubertal with ages between 7 and 13 years and 24 were postpubertal with ages between 19 and 39 years. Their testes were evaluated at 1.5 T with magnetic resonance spectroscopy; in addition, testis volumes were measured. Major metabolite peaks were identified and their ratios were calculated. Metabolite differences of testis between pre- and postpubertal age were analyzed. Results Major constituents of spectra were 3.21 ppm choline and 0.9–1.3 ppm lipid peaks. At the echo time (TE) spectrum of 31 ms, choline/lipid ratios ranged from 0.35 to 8.30 (mean=1.87) in postpubertal males and from 0.06 to 5.45 (mean=0.88) in prepubertal males ( P <.013). At the TE spectrum of 136 ms, choline/lipid ratios ranged from 0.66 to 15.42 (mean=4.09) in postpubertal males and from 0.05 to 4.91 (mean=0.9) in prepubertal males ( P <.016). Conclusions Choline/lipid ratio was higher in the postpubertal period. The existence of higher choline peak in that age group should be due to the initiation of spermatogenesis. The decrease in the lipid peak may represent the effect of testosterone on testicular tissue or may be due to histochemical changes initiated by puberty. The significant decrease in choline/lipid ratio noted after puberty could represent the presence of spermatogenesis. This hypothesis should be evaluated by further studies on postpubertal subjects with impaired spermatogenesis.</description><subject>Radiology</subject><issn>0730-725X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqljj1OAzEQRl0EifBzALq5QMx4ze5GKdIgUCoaKOgsy8yGWbz2ymOQ9vYkEjegevqkp09PqTuD2qDp7kc9FdYNYq-x04jblVpjb3HTN-37pboSGRGxbWy7Vi8GDjD5Y6LKAQpJTj4FApkp1JIl5HmBPED9JEi5TD5CJaksO5gLRZ44-bLAwOmD01Fu1MXgo9DtH6_V_vnp7fGwodP4YSouRE4cfPyihWTM3yWdPGecNA7d6znzXIk9on3orP33wS8gZlYS</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Firat, Ahmet Kemal</creator><creator>Uğraş, Murat</creator><creator>Karakaş, Hakkı M</creator><creator>Erdem, Gülnur</creator><creator>Kurus, Meltem</creator><creator>Ugras, Meltem</creator><creator>Celik, Tayfun</creator><creator>Kahraman, Bayram</creator><creator>Doğanay, Selim</creator><scope/></search><sort><creationdate>2008</creationdate><title>1 H magnetic resonance spectroscopy of the normal testis: preliminary findings</title><author>Firat, Ahmet Kemal ; Uğraş, Murat ; Karakaş, Hakkı M ; Erdem, Gülnur ; Kurus, Meltem ; Ugras, Meltem ; Celik, Tayfun ; Kahraman, Bayram ; Doğanay, Selim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S0730725X070034633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Radiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Firat, Ahmet Kemal</creatorcontrib><creatorcontrib>Uğraş, Murat</creatorcontrib><creatorcontrib>Karakaş, Hakkı M</creatorcontrib><creatorcontrib>Erdem, Gülnur</creatorcontrib><creatorcontrib>Kurus, Meltem</creatorcontrib><creatorcontrib>Ugras, Meltem</creatorcontrib><creatorcontrib>Celik, Tayfun</creatorcontrib><creatorcontrib>Kahraman, Bayram</creatorcontrib><creatorcontrib>Doğanay, Selim</creatorcontrib><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Firat, Ahmet Kemal</au><au>Uğraş, Murat</au><au>Karakaş, Hakkı M</au><au>Erdem, Gülnur</au><au>Kurus, Meltem</au><au>Ugras, Meltem</au><au>Celik, Tayfun</au><au>Kahraman, Bayram</au><au>Doğanay, Selim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1 H magnetic resonance spectroscopy of the normal testis: preliminary findings</atitle><jtitle>Magnetic resonance imaging</jtitle><date>2008</date><risdate>2008</risdate><volume>26</volume><issue>2</issue><spage>215</spage><epage>220</epage><pages>215-220</pages><issn>0730-725X</issn><abstract>Abstract Purpose The purpose of this study was to determine the pre- and postpubertal1 H magnetic resonance spectroscopic characteristics of the normal testis to establish baseline values for further clinical studies. Materials and Methods The subjects consisted of male volunteers, of whom 19 were prepubertal with ages between 7 and 13 years and 24 were postpubertal with ages between 19 and 39 years. Their testes were evaluated at 1.5 T with magnetic resonance spectroscopy; in addition, testis volumes were measured. Major metabolite peaks were identified and their ratios were calculated. Metabolite differences of testis between pre- and postpubertal age were analyzed. Results Major constituents of spectra were 3.21 ppm choline and 0.9–1.3 ppm lipid peaks. At the echo time (TE) spectrum of 31 ms, choline/lipid ratios ranged from 0.35 to 8.30 (mean=1.87) in postpubertal males and from 0.06 to 5.45 (mean=0.88) in prepubertal males ( P <.013). At the TE spectrum of 136 ms, choline/lipid ratios ranged from 0.66 to 15.42 (mean=4.09) in postpubertal males and from 0.05 to 4.91 (mean=0.9) in prepubertal males ( P <.016). Conclusions Choline/lipid ratio was higher in the postpubertal period. The existence of higher choline peak in that age group should be due to the initiation of spermatogenesis. The decrease in the lipid peak may represent the effect of testosterone on testicular tissue or may be due to histochemical changes initiated by puberty. The significant decrease in choline/lipid ratio noted after puberty could represent the presence of spermatogenesis. This hypothesis should be evaluated by further studies on postpubertal subjects with impaired spermatogenesis.</abstract><doi>10.1016/j.mri.2007.06.008</doi></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Radiology |
| title | 1 H magnetic resonance spectroscopy of the normal testis: preliminary findings |
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