H2 O2 -triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics

Abstract Overproduction of reactive oxygen species (ROS) such as hydrogen peroxide (H2 O2 ) leads to oxidative stress, causing inflammation and cellular damages and death. H2 O2 is one of the most stable and abundant ROS and H2 O2 -mediated oxidative stress is considered as a key mediator of cellula...

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Veröffentlicht in:Biomaterials 2016, Vol.85, p.195-203
Hauptverfasser: Kang, Changsun, Cho, Wooram, Park, Minhyung, Kim, Jinsub, Park, Sanghoon, Shin, Dongho, Song, Chulgyu, Lee, Dongwon
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container_end_page 203
container_issue
container_start_page 195
container_title Biomaterials
container_volume 85
creator Kang, Changsun
Cho, Wooram
Park, Minhyung
Kim, Jinsub
Park, Sanghoon
Shin, Dongho
Song, Chulgyu
Lee, Dongwon
description Abstract Overproduction of reactive oxygen species (ROS) such as hydrogen peroxide (H2 O2 ) leads to oxidative stress, causing inflammation and cellular damages and death. H2 O2 is one of the most stable and abundant ROS and H2 O2 -mediated oxidative stress is considered as a key mediator of cellular and tissue damages during ischemia/reperfusion (I/R) injury. Therefore, H2 O2 could hold tremendous potential as a diagnostic biomarker and therapeutic target for oxidative stress-associated inflammatory conditions such as I/R injury. Here, we report a novel nanotheranostic agent that can express ultrasound imaging and simultaneous therapeutic effects for hepatic I/R treatment, which is based on H2 O2 -triggered CO2 -generating antioxidant poly(vanillin oxalate) (PVO). PVO nanoparticles generate CO2 through H2 O2 -triggered oxidation of peroxalate esters and release vanillin, which exerts antioxidant and anti-inflammatory activities. PVO nanoparticles intravenously administrated remarkably enhanced the ultrasound signal in the site of hepatic I/R injury and also effectively suppressed the liver damages by inhibiting inflammation and apoptosis. To our best understanding, H2 O2 -responsive PVO is the first platform which generates bubbles to serve as ultrasound contrast agents and also exerts therapeutic activities. We therefore anticipate that H2 O2 -triggered bubble-generating antioxidant PVO nanoparticles have great potential for ultrasound imaging and therapy of H2 O2 -associated diseases.
doi_str_mv 10.1016/j.biomaterials.2016.01.070
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H2 O2 is one of the most stable and abundant ROS and H2 O2 -mediated oxidative stress is considered as a key mediator of cellular and tissue damages during ischemia/reperfusion (I/R) injury. Therefore, H2 O2 could hold tremendous potential as a diagnostic biomarker and therapeutic target for oxidative stress-associated inflammatory conditions such as I/R injury. Here, we report a novel nanotheranostic agent that can express ultrasound imaging and simultaneous therapeutic effects for hepatic I/R treatment, which is based on H2 O2 -triggered CO2 -generating antioxidant poly(vanillin oxalate) (PVO). PVO nanoparticles generate CO2 through H2 O2 -triggered oxidation of peroxalate esters and release vanillin, which exerts antioxidant and anti-inflammatory activities. PVO nanoparticles intravenously administrated remarkably enhanced the ultrasound signal in the site of hepatic I/R injury and also effectively suppressed the liver damages by inhibiting inflammation and apoptosis. To our best understanding, H2 O2 -responsive PVO is the first platform which generates bubbles to serve as ultrasound contrast agents and also exerts therapeutic activities. 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title H2 O2 -triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics
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