H2 O2 -triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics
Abstract Overproduction of reactive oxygen species (ROS) such as hydrogen peroxide (H2 O2 ) leads to oxidative stress, causing inflammation and cellular damages and death. H2 O2 is one of the most stable and abundant ROS and H2 O2 -mediated oxidative stress is considered as a key mediator of cellula...
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Veröffentlicht in: | Biomaterials 2016, Vol.85, p.195-203 |
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creator | Kang, Changsun Cho, Wooram Park, Minhyung Kim, Jinsub Park, Sanghoon Shin, Dongho Song, Chulgyu Lee, Dongwon |
description | Abstract Overproduction of reactive oxygen species (ROS) such as hydrogen peroxide (H2 O2 ) leads to oxidative stress, causing inflammation and cellular damages and death. H2 O2 is one of the most stable and abundant ROS and H2 O2 -mediated oxidative stress is considered as a key mediator of cellular and tissue damages during ischemia/reperfusion (I/R) injury. Therefore, H2 O2 could hold tremendous potential as a diagnostic biomarker and therapeutic target for oxidative stress-associated inflammatory conditions such as I/R injury. Here, we report a novel nanotheranostic agent that can express ultrasound imaging and simultaneous therapeutic effects for hepatic I/R treatment, which is based on H2 O2 -triggered CO2 -generating antioxidant poly(vanillin oxalate) (PVO). PVO nanoparticles generate CO2 through H2 O2 -triggered oxidation of peroxalate esters and release vanillin, which exerts antioxidant and anti-inflammatory activities. PVO nanoparticles intravenously administrated remarkably enhanced the ultrasound signal in the site of hepatic I/R injury and also effectively suppressed the liver damages by inhibiting inflammation and apoptosis. To our best understanding, H2 O2 -responsive PVO is the first platform which generates bubbles to serve as ultrasound contrast agents and also exerts therapeutic activities. We therefore anticipate that H2 O2 -triggered bubble-generating antioxidant PVO nanoparticles have great potential for ultrasound imaging and therapy of H2 O2 -associated diseases. |
doi_str_mv | 10.1016/j.biomaterials.2016.01.070 |
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H2 O2 is one of the most stable and abundant ROS and H2 O2 -mediated oxidative stress is considered as a key mediator of cellular and tissue damages during ischemia/reperfusion (I/R) injury. Therefore, H2 O2 could hold tremendous potential as a diagnostic biomarker and therapeutic target for oxidative stress-associated inflammatory conditions such as I/R injury. Here, we report a novel nanotheranostic agent that can express ultrasound imaging and simultaneous therapeutic effects for hepatic I/R treatment, which is based on H2 O2 -triggered CO2 -generating antioxidant poly(vanillin oxalate) (PVO). PVO nanoparticles generate CO2 through H2 O2 -triggered oxidation of peroxalate esters and release vanillin, which exerts antioxidant and anti-inflammatory activities. PVO nanoparticles intravenously administrated remarkably enhanced the ultrasound signal in the site of hepatic I/R injury and also effectively suppressed the liver damages by inhibiting inflammation and apoptosis. To our best understanding, H2 O2 -responsive PVO is the first platform which generates bubbles to serve as ultrasound contrast agents and also exerts therapeutic activities. We therefore anticipate that H2 O2 -triggered bubble-generating antioxidant PVO nanoparticles have great potential for ultrasound imaging and therapy of H2 O2 -associated diseases.</description><identifier>ISSN: 0142-9612</identifier><identifier>DOI: 10.1016/j.biomaterials.2016.01.070</identifier><language>eng</language><subject>Advanced Basic Science ; Dentistry</subject><ispartof>Biomaterials, 2016, Vol.85, p.195-203</ispartof><rights>Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27925,27926,27927</link.rule.ids></links><search><creatorcontrib>Kang, Changsun</creatorcontrib><creatorcontrib>Cho, Wooram</creatorcontrib><creatorcontrib>Park, Minhyung</creatorcontrib><creatorcontrib>Kim, Jinsub</creatorcontrib><creatorcontrib>Park, Sanghoon</creatorcontrib><creatorcontrib>Shin, Dongho</creatorcontrib><creatorcontrib>Song, Chulgyu</creatorcontrib><creatorcontrib>Lee, Dongwon</creatorcontrib><title>H2 O2 -triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics</title><title>Biomaterials</title><description>Abstract Overproduction of reactive oxygen species (ROS) such as hydrogen peroxide (H2 O2 ) leads to oxidative stress, causing inflammation and cellular damages and death. H2 O2 is one of the most stable and abundant ROS and H2 O2 -mediated oxidative stress is considered as a key mediator of cellular and tissue damages during ischemia/reperfusion (I/R) injury. Therefore, H2 O2 could hold tremendous potential as a diagnostic biomarker and therapeutic target for oxidative stress-associated inflammatory conditions such as I/R injury. Here, we report a novel nanotheranostic agent that can express ultrasound imaging and simultaneous therapeutic effects for hepatic I/R treatment, which is based on H2 O2 -triggered CO2 -generating antioxidant poly(vanillin oxalate) (PVO). PVO nanoparticles generate CO2 through H2 O2 -triggered oxidation of peroxalate esters and release vanillin, which exerts antioxidant and anti-inflammatory activities. PVO nanoparticles intravenously administrated remarkably enhanced the ultrasound signal in the site of hepatic I/R injury and also effectively suppressed the liver damages by inhibiting inflammation and apoptosis. To our best understanding, H2 O2 -responsive PVO is the first platform which generates bubbles to serve as ultrasound contrast agents and also exerts therapeutic activities. We therefore anticipate that H2 O2 -triggered bubble-generating antioxidant PVO nanoparticles have great potential for ultrasound imaging and therapy of H2 O2 -associated diseases.</description><subject>Advanced Basic Science</subject><subject>Dentistry</subject><issn>0142-9612</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqljzFPwzAQhT2ARKH8B4s96dlUQV1YEKgbAwxsluNe3QuOHfkc1P57HIl_wPT0Tu--uyfEg4JWgeo2Q9tTGm3BTDZwq-usBdXCE1yJFaitbnad0jfilnmA6mGrV-K81_Jdy6Zk8h4zHmQ_931A6TFitoWilzYWSmc6VJVTCpexXnAy2pgmmwu5gCwtS2J3wpHsJuOE-TgzpSiLzR5LxS7xcqrImLju8FpcH-ubeP-nd-L57fXzZd9gNT-E2bhAkZwN33hBHtKcY80ZZVgbMB9LoaWP6gBg1309_hvwC-6pajI</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Kang, Changsun</creator><creator>Cho, Wooram</creator><creator>Park, Minhyung</creator><creator>Kim, Jinsub</creator><creator>Park, Sanghoon</creator><creator>Shin, Dongho</creator><creator>Song, Chulgyu</creator><creator>Lee, Dongwon</creator><scope/></search><sort><creationdate>2016</creationdate><title>H2 O2 -triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics</title><author>Kang, Changsun ; Cho, Wooram ; Park, Minhyung ; Kim, Jinsub ; Park, Sanghoon ; Shin, Dongho ; Song, Chulgyu ; Lee, Dongwon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S014296121600096X3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Advanced Basic Science</topic><topic>Dentistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Changsun</creatorcontrib><creatorcontrib>Cho, Wooram</creatorcontrib><creatorcontrib>Park, Minhyung</creatorcontrib><creatorcontrib>Kim, Jinsub</creatorcontrib><creatorcontrib>Park, Sanghoon</creatorcontrib><creatorcontrib>Shin, Dongho</creatorcontrib><creatorcontrib>Song, Chulgyu</creatorcontrib><creatorcontrib>Lee, Dongwon</creatorcontrib><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Changsun</au><au>Cho, Wooram</au><au>Park, Minhyung</au><au>Kim, Jinsub</au><au>Park, Sanghoon</au><au>Shin, Dongho</au><au>Song, Chulgyu</au><au>Lee, Dongwon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>H2 O2 -triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics</atitle><jtitle>Biomaterials</jtitle><date>2016</date><risdate>2016</risdate><volume>85</volume><spage>195</spage><epage>203</epage><pages>195-203</pages><issn>0142-9612</issn><abstract>Abstract Overproduction of reactive oxygen species (ROS) such as hydrogen peroxide (H2 O2 ) leads to oxidative stress, causing inflammation and cellular damages and death. H2 O2 is one of the most stable and abundant ROS and H2 O2 -mediated oxidative stress is considered as a key mediator of cellular and tissue damages during ischemia/reperfusion (I/R) injury. Therefore, H2 O2 could hold tremendous potential as a diagnostic biomarker and therapeutic target for oxidative stress-associated inflammatory conditions such as I/R injury. Here, we report a novel nanotheranostic agent that can express ultrasound imaging and simultaneous therapeutic effects for hepatic I/R treatment, which is based on H2 O2 -triggered CO2 -generating antioxidant poly(vanillin oxalate) (PVO). PVO nanoparticles generate CO2 through H2 O2 -triggered oxidation of peroxalate esters and release vanillin, which exerts antioxidant and anti-inflammatory activities. PVO nanoparticles intravenously administrated remarkably enhanced the ultrasound signal in the site of hepatic I/R injury and also effectively suppressed the liver damages by inhibiting inflammation and apoptosis. To our best understanding, H2 O2 -responsive PVO is the first platform which generates bubbles to serve as ultrasound contrast agents and also exerts therapeutic activities. We therefore anticipate that H2 O2 -triggered bubble-generating antioxidant PVO nanoparticles have great potential for ultrasound imaging and therapy of H2 O2 -associated diseases.</abstract><doi>10.1016/j.biomaterials.2016.01.070</doi></addata></record> |
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title | H2 O2 -triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics |
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