Impaired Outcome Colitis Associated Rectal Cancer Versus Sporadic
Abstract Background The surgical management of colitis-associated rectal cancer is not well defined. This study determines outcomes after surgery for colitis-associated rectal cancer compared to sporadic rectal cancer. Materials and Methods This is a retrospective cohort study comparing 27 patients...
Gespeichert in:
| Veröffentlicht in: | The Journal of surgical research 2016 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | The Journal of surgical research |
| container_volume | |
| creator | Klos, Coen Safar, Bashar Wise, Paul E Hunt, Steven R Mutch, Matthew G Birnbaum, Elisa H Fleshman, James W Dharmarajan, Sekhar |
| description | Abstract Background The surgical management of colitis-associated rectal cancer is not well defined. This study determines outcomes after surgery for colitis-associated rectal cancer compared to sporadic rectal cancer. Materials and Methods This is a retrospective cohort study comparing 27 patients with colitis-associated rectal cancer to 54 matched patients with sporadic cancer. Matching criteria included age, gender, neoadjuvant chemoradiation and AJCC stage. Outcome measures were disease-free and overall survival, tumor characteristics, and postoperative morbidity. Results Compared to those with sporadic rectal cancer, patients with colitis-associated rectal cancer underwent proctocolectomy more frequently [21 (78%) vs. 6 (22%) p |
| doi_str_mv | 10.1016/j.jss.2016.03.006 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier</sourceid><recordid>TN_cdi_elsevier_clinicalkeyesjournals_1_s2_0_S0022480416001074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0022480416001074</els_id><sourcerecordid>1_s2_0_S0022480416001074</sourcerecordid><originalsourceid>FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S00224804160010743</originalsourceid><addsrcrecordid>eNqljk0KwjAUhLNQsP4cwF0uYHxpS6sbQYqiK0HFbQjxCamxkbxW8PZG8AauZj5mGIaxqQQhQRbzWtREIo1WQCYAih5LANJ0li8gH7AhUQ2Rl2WWsPX-8dQ24JUfutb4B_LKO9ta4msib6xuY3RE02rHK90YDPyCgTrip6cP-mrNmPVv2hFOfjpiq-3mXO1mGOFlMSjjbGONdnd8I9W-C03sKakoVaBO32ffY7IAkFDm2d8DHwxbUEQ</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Impaired Outcome Colitis Associated Rectal Cancer Versus Sporadic</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Klos, Coen ; Safar, Bashar ; Wise, Paul E ; Hunt, Steven R ; Mutch, Matthew G ; Birnbaum, Elisa H ; Fleshman, James W ; Dharmarajan, Sekhar</creator><creatorcontrib>Klos, Coen ; Safar, Bashar ; Wise, Paul E ; Hunt, Steven R ; Mutch, Matthew G ; Birnbaum, Elisa H ; Fleshman, James W ; Dharmarajan, Sekhar</creatorcontrib><description>Abstract Background The surgical management of colitis-associated rectal cancer is not well defined. This study determines outcomes after surgery for colitis-associated rectal cancer compared to sporadic rectal cancer. Materials and Methods This is a retrospective cohort study comparing 27 patients with colitis-associated rectal cancer to 54 matched patients with sporadic cancer. Matching criteria included age, gender, neoadjuvant chemoradiation and AJCC stage. Outcome measures were disease-free and overall survival, tumor characteristics, and postoperative morbidity. Results Compared to those with sporadic rectal cancer, patients with colitis-associated rectal cancer underwent proctocolectomy more frequently [21 (78%) vs. 6 (22%) p<0.001], and were more likely to have mucinous tumors [11 (40.7%) vs. 12 (22.3%) p=0.03]. Overall 3 year survival was significantly reduced in colitis-associated rectal cancer patients compared to patients with sporadic rectal cancer. Those with colitis-associated rectal cancer undergoing segmental proctectomy only, demonstrated reduced overall and disease-free survival compared to patients with sporadic rectal cancer, and to colitis patients undergoing proctocolectomy [p=0.002]. Conclusions Patients with colitis-associated rectal cancer undergoing proctectomy demonstrate reduced disease-free survival versus those undergoing proctocolectomy, and versus patients with sporadic rectal cancer undergoing proctectomy. These findings warrant further study and suggest that proctocolectomy should be considered the preferred surgical approach for colitis-associated rectal cancer.</description><identifier>ISSN: 0022-4804</identifier><identifier>DOI: 10.1016/j.jss.2016.03.006</identifier><language>eng</language><subject>Surgery</subject><ispartof>The Journal of surgical research, 2016</ispartof><rights>Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Klos, Coen</creatorcontrib><creatorcontrib>Safar, Bashar</creatorcontrib><creatorcontrib>Wise, Paul E</creatorcontrib><creatorcontrib>Hunt, Steven R</creatorcontrib><creatorcontrib>Mutch, Matthew G</creatorcontrib><creatorcontrib>Birnbaum, Elisa H</creatorcontrib><creatorcontrib>Fleshman, James W</creatorcontrib><creatorcontrib>Dharmarajan, Sekhar</creatorcontrib><title>Impaired Outcome Colitis Associated Rectal Cancer Versus Sporadic</title><title>The Journal of surgical research</title><description>Abstract Background The surgical management of colitis-associated rectal cancer is not well defined. This study determines outcomes after surgery for colitis-associated rectal cancer compared to sporadic rectal cancer. Materials and Methods This is a retrospective cohort study comparing 27 patients with colitis-associated rectal cancer to 54 matched patients with sporadic cancer. Matching criteria included age, gender, neoadjuvant chemoradiation and AJCC stage. Outcome measures were disease-free and overall survival, tumor characteristics, and postoperative morbidity. Results Compared to those with sporadic rectal cancer, patients with colitis-associated rectal cancer underwent proctocolectomy more frequently [21 (78%) vs. 6 (22%) p<0.001], and were more likely to have mucinous tumors [11 (40.7%) vs. 12 (22.3%) p=0.03]. Overall 3 year survival was significantly reduced in colitis-associated rectal cancer patients compared to patients with sporadic rectal cancer. Those with colitis-associated rectal cancer undergoing segmental proctectomy only, demonstrated reduced overall and disease-free survival compared to patients with sporadic rectal cancer, and to colitis patients undergoing proctocolectomy [p=0.002]. Conclusions Patients with colitis-associated rectal cancer undergoing proctectomy demonstrate reduced disease-free survival versus those undergoing proctocolectomy, and versus patients with sporadic rectal cancer undergoing proctectomy. These findings warrant further study and suggest that proctocolectomy should be considered the preferred surgical approach for colitis-associated rectal cancer.</description><subject>Surgery</subject><issn>0022-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqljk0KwjAUhLNQsP4cwF0uYHxpS6sbQYqiK0HFbQjxCamxkbxW8PZG8AauZj5mGIaxqQQhQRbzWtREIo1WQCYAih5LANJ0li8gH7AhUQ2Rl2WWsPX-8dQ24JUfutb4B_LKO9ta4msib6xuY3RE02rHK90YDPyCgTrip6cP-mrNmPVv2hFOfjpiq-3mXO1mGOFlMSjjbGONdnd8I9W-C03sKakoVaBO32ffY7IAkFDm2d8DHwxbUEQ</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Klos, Coen</creator><creator>Safar, Bashar</creator><creator>Wise, Paul E</creator><creator>Hunt, Steven R</creator><creator>Mutch, Matthew G</creator><creator>Birnbaum, Elisa H</creator><creator>Fleshman, James W</creator><creator>Dharmarajan, Sekhar</creator><scope/></search><sort><creationdate>2016</creationdate><title>Impaired Outcome Colitis Associated Rectal Cancer Versus Sporadic</title><author>Klos, Coen ; Safar, Bashar ; Wise, Paul E ; Hunt, Steven R ; Mutch, Matthew G ; Birnbaum, Elisa H ; Fleshman, James W ; Dharmarajan, Sekhar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S00224804160010743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klos, Coen</creatorcontrib><creatorcontrib>Safar, Bashar</creatorcontrib><creatorcontrib>Wise, Paul E</creatorcontrib><creatorcontrib>Hunt, Steven R</creatorcontrib><creatorcontrib>Mutch, Matthew G</creatorcontrib><creatorcontrib>Birnbaum, Elisa H</creatorcontrib><creatorcontrib>Fleshman, James W</creatorcontrib><creatorcontrib>Dharmarajan, Sekhar</creatorcontrib><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klos, Coen</au><au>Safar, Bashar</au><au>Wise, Paul E</au><au>Hunt, Steven R</au><au>Mutch, Matthew G</au><au>Birnbaum, Elisa H</au><au>Fleshman, James W</au><au>Dharmarajan, Sekhar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Outcome Colitis Associated Rectal Cancer Versus Sporadic</atitle><jtitle>The Journal of surgical research</jtitle><date>2016</date><risdate>2016</risdate><issn>0022-4804</issn><abstract>Abstract Background The surgical management of colitis-associated rectal cancer is not well defined. This study determines outcomes after surgery for colitis-associated rectal cancer compared to sporadic rectal cancer. Materials and Methods This is a retrospective cohort study comparing 27 patients with colitis-associated rectal cancer to 54 matched patients with sporadic cancer. Matching criteria included age, gender, neoadjuvant chemoradiation and AJCC stage. Outcome measures were disease-free and overall survival, tumor characteristics, and postoperative morbidity. Results Compared to those with sporadic rectal cancer, patients with colitis-associated rectal cancer underwent proctocolectomy more frequently [21 (78%) vs. 6 (22%) p<0.001], and were more likely to have mucinous tumors [11 (40.7%) vs. 12 (22.3%) p=0.03]. Overall 3 year survival was significantly reduced in colitis-associated rectal cancer patients compared to patients with sporadic rectal cancer. Those with colitis-associated rectal cancer undergoing segmental proctectomy only, demonstrated reduced overall and disease-free survival compared to patients with sporadic rectal cancer, and to colitis patients undergoing proctocolectomy [p=0.002]. Conclusions Patients with colitis-associated rectal cancer undergoing proctectomy demonstrate reduced disease-free survival versus those undergoing proctocolectomy, and versus patients with sporadic rectal cancer undergoing proctectomy. These findings warrant further study and suggest that proctocolectomy should be considered the preferred surgical approach for colitis-associated rectal cancer.</abstract><doi>10.1016/j.jss.2016.03.006</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4804 |
| ispartof | The Journal of surgical research, 2016 |
| issn | 0022-4804 |
| language | eng |
| recordid | cdi_elsevier_clinicalkeyesjournals_1_s2_0_S0022480416001074 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Surgery |
| title | Impaired Outcome Colitis Associated Rectal Cancer Versus Sporadic |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T15%3A17%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impaired%20Outcome%20Colitis%20Associated%20Rectal%20Cancer%20Versus%20Sporadic&rft.jtitle=The%20Journal%20of%20surgical%20research&rft.au=Klos,%20Coen&rft.date=2016&rft.issn=0022-4804&rft_id=info:doi/10.1016/j.jss.2016.03.006&rft_dat=%3Celsevier%3E1_s2_0_S0022480416001074%3C/elsevier%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_els_id=1_s2_0_S0022480416001074&rfr_iscdi=true |