Ryanodine receptor modification and regulation by intracellular Ca 2 + and Mg 2 + in healthy and failing human hearts

Abstract Rationale Heart failure is a multimodal disorder, of which disrupted Ca 2 + homeostasis is a hallmark. Central to Ca 2 + homeostasis is the major cardiac Ca 2 + release channel – the ryanodine receptor (RyR2) – whose activity is influenced by associated proteins, covalent modification and b...

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