Obesity-Induced Increase in Tumor Necrosis Factor-α Leads to Development of Colon Cancer in Mice

Background & Aims Epidemiology studies have shown that obesity increases risk for colorectal cancer (CRC). We investigated the contribution of obesity-induced increases in levels of tumor necrosis factor (TNF)-α and hyperinsulinemia to the development of CRC in mice. Methods Lean and obese mice...

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2012, Vol.143 (3), p.741-753.e4
Hauptverfasser: Flores, Marcelo B.S, Rocha, Guilherme Z, Damas–Souza, Danilo M, Osório–Costa, Felipe, Dias, Marília M, Ropelle, Eduardo R, Camargo, Juliana A, de Carvalho, Rita B, Carvalho, Hernandes F, Saad, Mario J.A, Carvalheira, José B.C
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Sprache:eng
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