A Sand Fly Salivary Protein Vaccine Shows Efficacy Against Vector-Transmitted Cutaneous Leishmaniasis in Nonhuman Primates

Currently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman...

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Bibliographische Detailangaben
Hauptverfasser:	Oliveira, Fabiano, Rowton, Edgar, Aslan, Hamide, Gomes, Regis, Castrovinci, Philip A, Alvarenga, Patricia H, Abdeladhim, Maha, Teixeira, Clarissa, Meneses, Claudio, Kleeman, Lindsey T
Format:	Report
Sprache:	eng
Schlagworte:	ACCELERATED TESTING Anatomy and Physiology ANTIGEN ANTIBODY REACTIONS ASSAYING Biochemistry BITES AND STINGS BLOOD CELLS CULTURES(BIOLOGY) CYTOKINES DIPTERA DISEASE VECTORS ENZYMES EXPOSURE(PHYSIOLOGY) HISTOLOGY HOSTS(BIOLOGY) IMMUNOGENS INFECTED BITES INFECTIOUS DISEASES LEISHMANIASIS Medicine and Medical Research NHP(NONHUMAN PRIMATES) PARASITES PATHOPHYSIOLOGY PRIMATES PROTEINS RECEPTOR SITES(PHYSIOLOGY) RESPONSE(BIOLOGY) RODENTS SALIVA SAND FLIES SKIN TESTS STATISTICAL ANALYSIS TARGETS WINGED INSECTS
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