Comparison of Clinical Presentation of Acute Myocarditis Following Smallpox Vaccination to Acute Coronary Syndromes in Patients 40 Years of Age

Smallpox vaccine-associated myopericarditis may have a similar presentation to acute coronary syndrome (ACS). The clinical records of 78 young patients (40 years of age) presenting with ACS (n=16) or myocarditis after smallpox vaccination (n=62) were reviewed. Comparisons were made among clinical pr...

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Hauptverfasser:	Eckart, Robert E, Shry, Eric A, Jones, IV, Samuel O, Atwood, J E, Grabenstein, John D
Format:	Report
Sprache:	eng
Schlagworte:	ACUTE CORONARY SYNDROME ACUTE MYOCARDIAL INFARCTION ADVERSE EFFECTS ADVERSE REACTIONS Anatomy and Physiology ATHEROSCLEROSIS AUTOIMMUNE REACTIONS Biochemistry CARDIAC ENZYMES CARDIAC RISK FACTORS CHEST PAIN CLINICAL PRESENTATION CREATINE KINASE DEMOGRAPHY DIAGNOSIS(MEDICINE) ECHOCARDIOGRAPHY ELECTROCARDIOGRAPHY ENZYMES FOCAL WALL MOTION ABNORMALITIES IMMUNIZATION INFLAMMATION Medicine and Medical Research Military Forces and Organizations MILITARY FORCES(UNITED STATES) MILITARY PERSONNEL MYOCARDITIS MYOCARDIUM MYOPERICARDITIS PAIN PATIENTS PEAK VALUES PERICARDIUM PHYSIOLOGICAL EFFECTS POSTVACCINIAL MYOCARDITIS REPRINTS TROPONIN-I VACCINES VARIOLA VIRUS
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Zusammenfassung:	Smallpox vaccine-associated myopericarditis may have a similar presentation to acute coronary syndrome (ACS). The clinical records of 78 young patients (40 years of age) presenting with ACS (n=16) or myocarditis after smallpox vaccination (n=62) were reviewed. Comparisons were made among clinical presentation, cardiac enzymes, echocardiographic findings, and electrocardiographic changes. The presence of cardiac risk factors or focal wall motion abnormalities on echocardiography were associated with a diagnosis of ACS. There was a trend toward earlier elevation of troponin-I and creatine kinase in patients with myocarditis compared with ACS. Published in The American Journal of Cardiology, v95, p1252-1255, 15 May 2005.