Hypothermia Induction and Recovery in Free-Ranging Rats

1. To avoid anesthesia confounders, free-ranging rats were exposed to cool water, warm water, or temperate air to induce hypothermia, or control for water or novel environment stress, respectively. 2. While WW and TA core temperature and the brown adipose tissue subdermal skin temperature relationsh...

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Hauptverfasser: DuBose, D A, Leon, L R, Morehouse, D H, Rufolo, D M, Blaha, M D, Gordon, C J
Format: Report
Sprache:eng
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Zusammenfassung:1. To avoid anesthesia confounders, free-ranging rats were exposed to cool water, warm water, or temperate air to induce hypothermia, or control for water or novel environment stress, respectively. 2. While WW and TA core temperature and the brown adipose tissue subdermal skin temperature relationship remained similar, CW hypothermia induction was variable and associated with tachycardia or TA with CW TBAT elevated CW TSDS. 3. Without anesthesia to blunt thermoregulatory countermeasures to hypothermia, variable resistance to Tc depression, tachycardia rather than bradycardia and BAT thermogenic responses were demonstrated. Published in Journal of Thermal Biology, v32 p87-96, 2007. Prepared in cooperation with Environmental Protection Agency, Research Triangle Park, NC.