An Essential Function of the N-Terminus of Ira/Neurofibromin

The authors proposed to study a potentially new function of the yeast homolog of neurofibromin, Ira1. It is suggested from the literature that a complete deletion of Ira1 is lethal to yeast, while previous partial deletions of the same gene is viable. These seemingly conflicting results point to a p...

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1. Verfasser:	Ding, Vivianne
Format:	Report
Sprache:	eng
Schlagworte:	Biochemistry Biology DEFICIENCIES DELETION STRAINS DIPLOID STRAINS GENE EXPRESSION GENES Genetic Engineering and Molecular Biology GENOME GTPASE ACTIVATING PROTEINS HEAT SHOCK SENSITIVITY IRA1 DELETION IRA1 GENE LETHALITY MEDICAL RESEARCH MUTATIONS N-TERMINUS NEUROFIBROMATOSIS NEUROFIBROMIN PROTEINS RAS PROTEINS SACCHAROMYCETES SENSITIVITY STRAINS(BIOLOGY) TETRAD ANALYSIS THERMAL SHOCK YEAST HOMOLOGS YEASTS
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Zusammenfassung:	The authors proposed to study a potentially new function of the yeast homolog of neurofibromin, Ira1. It is suggested from the literature that a complete deletion of Ira1 is lethal to yeast, while previous partial deletions of the same gene is viable. These seemingly conflicting results point to a possible essential function of the N-terminus of Ira1. However, the authors found that in their hands, a complete deletion of Ira1 is viable. Tetrad analysis was also carried out in the strains provided by the Saccharomyces genome deletion consortium and they got the same result. Therefore, the N-terminus of Ira1 does not possess any essential function in the yeast strains they have tested. The original document contains color images.