Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis

Leishmaniasis, a disease caused by protozoan parasites of the Lesihsmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxi...

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1. Verfasser:	Nolan, Linda L
Format:	Report
Sprache:	eng
Schlagworte:	CHEMOTHERAPY DNA POLYMERASE AND S-ADENOSYLMETHIONINE SYNTHETASE ISOLATION AND CHARACTERIZATION DRUGS ENZYMES LEISHMANIA LEISHMANIASIS MADE OF ACTION OF PURINE ANOLOGS Medicine and Medical Research PARASITES PROTOZOA PUBLIC HEALTH TARGETING THERAPY TOXICITY
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creator	Nolan, Linda L
description	Leishmaniasis, a disease caused by protozoan parasites of the Lesihsmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to isolate and characterize unique leishmanial enzymes (DNA polymerase and S- adenosylsynthetase) for the purpose of chemotherapeutic exploitation.
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Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to isolate and characterize unique leishmanial enzymes (DNA polymerase and S- adenosylsynthetase) for the purpose of chemotherapeutic exploitation.</description><language>eng</language><subject>CHEMOTHERAPY ; DNA POLYMERASE AND S-ADENOSYLMETHIONINE SYNTHETASE ISOLATION AND CHARACTERIZATION ; DRUGS ; ENZYMES ; LEISHMANIA ; LEISHMANIASIS ; MADE OF ACTION OF PURINE ANOLOGS ; Medicine and Medical Research ; PARASITES ; PROTOZOA ; PUBLIC HEALTH ; TARGETING ; THERAPY ; TOXICITY</subject><creationdate>1991</creationdate><rights>Approved for public release; distribution is unlimited.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,781,886,27572,27573</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA238236$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Nolan, Linda L</creatorcontrib><creatorcontrib>MASSACHUSETTS UNIV AMHERST</creatorcontrib><title>Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis</title><description>Leishmaniasis, a disease caused by protozoan parasites of the Lesihsmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to isolate and characterize unique leishmanial enzymes (DNA polymerase and S- adenosylsynthetase) for the purpose of chemotherapeutic exploitation.</description><subject>CHEMOTHERAPY</subject><subject>DNA POLYMERASE AND S-ADENOSYLMETHIONINE SYNTHETASE ISOLATION AND CHARACTERIZATION</subject><subject>DRUGS</subject><subject>ENZYMES</subject><subject>LEISHMANIA</subject><subject>LEISHMANIASIS</subject><subject>MADE OF ACTION OF PURINE ANOLOGS</subject><subject>Medicine and Medical Research</subject><subject>PARASITES</subject><subject>PROTOZOA</subject><subject>PUBLIC HEALTH</subject><subject>TARGETING</subject><subject>THERAPY</subject><subject>TOXICITY</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1991</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZHB0zkjNzS_JSC1KLKhUSMxLUXApKk1XCEksSk8tycxLV8jMUwDKKoQUpSaW5KbmlSjkpyn4pGYWZ-Qm5mUmFmcW8zCwpiXmFKfyQmluBhk31xBnD92Ukszk-GKgIakl8Y4ujkbGFkbGZsYEpAH3qi6S</recordid><startdate>19910529</startdate><enddate>19910529</enddate><creator>Nolan, Linda L</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>19910529</creationdate><title>Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis</title><author>Nolan, Linda L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA2382363</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1991</creationdate><topic>CHEMOTHERAPY</topic><topic>DNA POLYMERASE AND S-ADENOSYLMETHIONINE SYNTHETASE ISOLATION AND CHARACTERIZATION</topic><topic>DRUGS</topic><topic>ENZYMES</topic><topic>LEISHMANIA</topic><topic>LEISHMANIASIS</topic><topic>MADE OF ACTION OF PURINE ANOLOGS</topic><topic>Medicine and Medical Research</topic><topic>PARASITES</topic><topic>PROTOZOA</topic><topic>PUBLIC HEALTH</topic><topic>TARGETING</topic><topic>THERAPY</topic><topic>TOXICITY</topic><toplevel>online_resources</toplevel><creatorcontrib>Nolan, Linda L</creatorcontrib><creatorcontrib>MASSACHUSETTS UNIV AMHERST</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Nolan, Linda L</au><aucorp>MASSACHUSETTS UNIV AMHERST</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis</btitle><date>1991-05-29</date><risdate>1991</risdate><abstract>Leishmaniasis, a disease caused by protozoan parasites of the Lesihsmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to isolate and characterize unique leishmanial enzymes (DNA polymerase and S- adenosylsynthetase) for the purpose of chemotherapeutic exploitation.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMOTHERAPY DNA POLYMERASE AND S-ADENOSYLMETHIONINE SYNTHETASE ISOLATION AND CHARACTERIZATION DRUGS ENZYMES LEISHMANIA LEISHMANIASIS MADE OF ACTION OF PURINE ANOLOGS Medicine and Medical Research PARASITES PROTOZOA PUBLIC HEALTH TARGETING THERAPY TOXICITY
title	Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis
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